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You are here: Home / Archives for antibody engineering

Join us on April 28th for our webinar on Fc silencing techniques!

April 12, 2022 by Janice Reichert

Registration is open!

Thursday April 28, 2022, 11am ET

Speaker: Ian Wilkinson, PhD

Antibodies are nature’s pro-drugs, wonderfully evolved to target pathogens and activate immune systems. For certain indications where ADCC or CDC are required this is ideal, but for many other applications activation of inflammatory responses is unnecessary and potentially highly undesirable. In these situations silenced antibodies with either naturally low effector function or engineered Fc domains are the preferred option. However, many of the commonly used options in the clinic, such as IgG4, LALA or aglycosylation, are widely reported to still have residual Fc receptor binding and cytokine activation in patients.

This presentation will describe the first thorough comparison of most of the generic and proprietary Fc silencing mutations, demonstrating that all previously reported variants show residual binding to Fc receptors. It will also describe the discovery of a novel set of mutations, known as STR, that show no detectable binding to Fcγ receptors and do not elicit inflammatory cytokine responses. Meanwhile, immunogenicity, stability and PK are unaffected. This totally silenced variant has the potential to improve the safety and efficacy of therapeutic antibodies and Fc fusion proteins.

Filed Under: Antibody engineering, Antibody therapeutic Tagged With: antibody engineering, antibody therapeutics, Fc engineering

Career Shorts Ep 2 – Dr Nimish Gera

October 18, 2021 by Raquel Ferro

After the launch of our new Career Shorts series last week, we are proud to release our second episode with Dr Nimish Gera, Head of Biologics at Mythic Therapeutics! Check out our new episode via our new YouTube channel using the link below.

Career Shorts Ep 2: https://youtu.be/kOpuBxNdS5A

 

Our previous episode (Ep 1 with Dr Li Zhou): https://youtu.be/Y9xtGRLQaSM
Career shorts webpage: https://www.antibodysociety.org/career-shorts/

About Career shorts:

In this series, we talk to scientists and individuals working within the world of antibodies about the experiences that have shaped their careers and have got them to where they are today. Our goal by sharing their experiences and advice is to empower the next generation of scientists and leaders working in this field and beyond to make confident and empowered decisions.

Filed Under: Antibody discovery, Careers Tagged With: antibody discovery, antibody engineering, Careers

2021 James S. Huston Antibody Science Talent Award winner is announced!

October 15, 2021 by Janice Reichert

We are delighted to announce that Dr. Laura M. Walker has been selected as the 2021 James S. Huston Antibody Science Talent Award Recipient!

Dr. Walker is the Senior Director of Antibody Sciences at Adimab and the Chief Scientific Officer and a co-founder of Adagio Therapeutics. Her team at Adimab is focused on understanding human B cell responses to viral infection and discovering broadly neutralizing antibodies to a wide variety of emerging viral pathogens, including Ebola, Zika, yellow fever, and SARS-CoV-2. At Adagio, Laura oversees a broad portfolio of research in the area of viral immunology, including the identification of potent and broadly neutralizing antibodies to advance into clinical development. Prior to joining Adimab in 2012, Dr. Walker earned her Ph.D. in Immunology and Microbiology in Prof. Dennis Burton’s laboratory at The Scripps Research Institute and completed a post-doctoral research fellowship in Immunology at The University of California-San Francisco. Dr. Walker has received multiple fellowships and awards, including the Endpoints News “The 20 under 40 in biopharma” award in 2020.

The James S. Huston Antibody Science Talent Award is sponsored by The Antibody Society to recognize and encourage upcoming scientists in the field of Antibody Engineering and Therapeutics. Early career research scientists who have received an advanced degree (Ph.D., M.D., or equivalent) within the past ten (10) years are eligible for the Award. The scientist is recognized for making important contributions to the antibody field and/or the dissemination of antibody knowledge. The recipient will be invited to give a lecture on their work, which will be made available on-line on The Antibody Society’s website, and to give a lecture at the Antibody Engineering & Therapeutics conference in December 2021.

The award includes: international recognition of the scientist’s accomplishments, a $1500 USD prize, and travel costs and registration fees to attend the annual Antibody Engineering & Therapeutics conference in San Diego, California.
 

Filed Under: Huston Award Tagged With: antibody engineering, Huston Award

Career Shorts

October 11, 2021 by Raquel Ferro

The Antibody Society is proud to present Career Shorts!

In this series, we talk to scientists and individuals working within the world of antibodies about the experiences that have shaped their careers and have got them to where they are today. Our goal by sharing their experiences and advice is to empower the next generation of scientists and leaders working in this field and beyond to make confident and empowered decisions.

We kick off our first episode by talking to Dr Li Zhou, principle scientist at AbbVie. This episode and more will be made accessible via our new YouTube channel. Check out the full interview in the link below and stay tuned for more exciting releases!

 

Career Shorts Ep 1: Dr Li Zhou: https://youtu.be/Y9xtGRLQaSM
Career shorts webpage: https://www.antibodysociety.org/career-shorts/

Filed Under: Antibody discovery, Career Shorts, Uncategorized Tagged With: antibody discovery, antibody engineering, career shorts, Careers

Antibody Engineering & Therapeutics Europe Poster Competition

March 9, 2021 by The Antibody Society

Attention Student and Post-doc Members!

The Antibody Engineering & Therapeutics Europe Poster Competition is now open.

This virtual meeting will be held June 8-10, 2021.

To recognize the research activities of promising student and postdoctoral members, The Antibody Society is sponsoring a poster competition for these members in which two winners will be selected to receive:

  • Free registration to attend this virtual conference;
  • An opportunity to present a virtual poster during the conference; 
  • A Digital Badge as a Winner of the Poster Competition; and
  • The Antibody Society’s Award of Excellence (shown above).

In order to be considered for this poster competition, you must be a student or postdoctoral fellow member of The Antibody Society and your poster abstract must be submitted using the poster submission form. Please be sure to check the box on the poster submission form indicating that you want your abstract to be considered for the poster competition.

The Poster submission deadline is April 30, 2021.
Winners will be notified by May 7, 2021.

Submit your poster here!

Poster abstracts may be submitted and accepted for presentation at the conference after April 30th, but any submissions received after April 30 will not be considered for the poster competition.

Not a member? Please join!

Filed Under: Competition, The Antibody Society Tagged With: antibody engineering, competition

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