Purpose:
The Inferred Allele Review Sub-committee (IARC) was formed after the third AIRR-Community meeting in Rockville, MD in December 2017. The IARC is responsible for judging the validity of germline immunoglobulin and TCR genes, inferred from RepSeq data. It advises IMGT and the IUIS/IMGT nomenclature committee of their findings. It also reviews inferred sequences, and evidence in support of their existence, and makes this data available to the AIRR community and other researchers through the OGRDB database. The work of the committee initially focused on human IGHV germline genes, but it is hoped that work will commence on the evaluation of other germline genes, and species.
Achievements:
- Begun collating data for inferred human IGHV alleles from interested researchers, and established a formal submission process.
- Developed criteria for the review and acceptance of inferred IGHV alleles.
- With William Lees and Adrian Shepherd of Birkbeck, University of London, co-developed OGRDB, a public resource for the submission, review and publication of previously unknown receptor germline sequences together with supporting evidence.
- In its first year of operation, 16 new IGHV alleles were approved by the IARC. All 16 sequences were subsequently given names by IUIS/IMGT Nomenclature Committee, and have been incorporated into the IMGT Reference Directory.
Further details, including evidence in support of the inferences, can be found at the OGRDB website.
Goals for 2021
- Continue to evaluate human IGH IGK, and IGL inferences
- Establish a human TCR IARC
- Establish IARC(s) for non-human species
- Develop tools and guidelines for the evaluation of the ‘quality’ of submitted datasets
- Streamline procedures for the submission and assessment of human IGHV inferences
- Develop strategies to make the work of the IARC(s) sustainable
Members:
Co-leader: Mats Ohlin
Members: Andrew Collins, Martin Corcoran, William Lees, Mats Ohlin (Co-lead), Corey Watson and Gur Yaari.
Related Resources:
The OGRDB database documents the evaluation process of each submitted gene sequence, and provides access to evidence in support of affirmed inferences.
The VDJbase database of genotypes and haplotypes is being developed in association with OGRDB, and provides evidence of the expression of germline genes in hundreds of individuals.
Discussion of some issues arising from activities of the Germline Database Working Group can be found at the B-T.CR Wiki.
Contact: iarc@airrc.antibodysociety.org
Meeting Minutes:
2021:
IARC Meeting 87 Minutes – 2021/11/24
IARC Meeting 86 Minutes – 2021/11/17
IARC Meeting 85 Minutes – 2021/11/1
IARC Meeting 84 Minutes – 2021/10/25
IARC Meeting 83 Minutes – 2021/10/18
IARC Meeting 82 Minutes – 2021/10/11
IARC Meeting 81 Minutes – 2021/10/4
IARC Meeting 80 Minutes – 2021/9/27
IARC Meeting 79 Minutes – 2021/9/6
IARC Meeting 78 Minutes – 2021/8/31
IARC Meeting 77 Minutes – 2021/8/24
IARC Meeting 76 Minutes – 2021/8/17
IARC Meeting 75 Minutes – 2021/8/10
IARC Meeting 74 Minutes – 2021/8/3
IARC Meeting 73 Minutes – 2021/7/13
IARC Meeting 72 Minutes – 2021/7/6
IARC Meeting 71 Minutes – 2021/6/29
IARC Meeting 70 Minutes – 2021/6/15
IARC Meeting 69 Minutes – 2021/5/18
IARC Meeting 68 Minutes – 2021/4/26
IARC Meeting 67 Minutes – 2021/4/6
IARC Meeting 66 Minutes – 2021/3/21
IARC Meeting 65 Minutes – 2021/2/9
IARC Meeting 64 Minutes – 2021/01/21
2020:
IARC Meeting 63 Minutes – 2020/11/20
IARC Meeting 62 Minutes – 2020/11/3
IARC Meeting 61 Minutes – 2020/10/13
IARC Meeting 60 Minutes – 2020/9/1
IARC Meeting 59 Minutes – 2020/8/20
IARC Meeting 58 Minutes – 2020/7/20
IARC Meeting 57 Minutes – 2020/7/7
IARC Meeting 56 Minutes – 2020/6/15
IARC Meeting 55 Minutes – 2020/5/26
IARC Meeting 54 Minutes – 2020/4/27
IARC Meeting 53 Minutes – 2020/4/14
IARC Meeting 52 Minutes – 2020/4/3
IARC Meeting 51 Minutes – 2020/3/16
IARC Meeting 50 Minutes – 2020/2/24
IARC Meeting 49 Minutes – 2020/2/4
IARC Meeting 48 Minutes – 2020/1/20
2019:
IARC Meeting 47 Minutes – 2019/12/9
IARC Meeting 46 Minutes – 2019/12/2
IARC Meeting 45 Minutes – 2019/11/18
IARC Meeting 44 Minutes – 2019/11/6
IARC Meeting 43 Minutes – 2019/10/7
IARC Meeting 42 Minutes – 2019/9/16
IARC Meeting 41 Minutes – 2019/8/19
IARC Meeting 40 Minutes – 2019/8/7
IARC Meeting 39 Minutes – 2019/7/10
IARC Meeting 38 Minutes – 2019/6/11
IARC Meeting 37 Minutes – 2019/5/31
IARC Meeting 36 Minutes – 2019/5/2
IARC Meeting 35 Minutes – 2019/4/19
IARC Meeting 34 Minutes – 2019/3/29
IARC Meeting 33 Minutes – 2019/3/15
IARC Meeting 32 Minutes – 2019/3/1
IARC Meeting 31 Minutes – 2019/2/8
IARC Meeting 30 Minutes – 2019/2/1
IARC Meeting 29 Minutes – 2019/1/25
2018:
IARC Meeting 28 Minutes – 2018/12/18
IARC Meeting 27 Minutes – 2018/12/7
IARC Meeting 26 Minutes – 2018/11/8
IARC Meeting 25 Minutes – 2018/9/28
IARC Meeting 24 Minutes – 2018/9/13
IARC Meeting 23 Minutes – 2018/8/24
IARC Meeting 22 Minutes – 2018/8/10
IARC Meeting 21 Minutes – 2018/7/27
IARC Meeting 20 Minutes – 2018/7/13
IARC Meeting 19 Minutes – 2018/6/19
IARC Meeting 18 Minutes – 2018/6/14
IARC Meeting 17 Minutes – 2018/6/1
IARC Meeting 16 Minutes – 2018/5/25
IARC Meeting 15 Minutes – 2018/5/18
IARC Meeting 14 Minutes – 2018/5/11
IARC Meeting 13 Minutes – 2018/5/2
IARC Meeting 12 Minutes – 2018/4/20
IARC Meeting 11 Minutes – 2018/4/13
IARC Meeting 10 Minutes – 2018/4/6
IARC Meeting 9 Minutes – 2018/3/28
IARC Meeting 8 Minutes – 2018/3/10
IARC Meeting 7 Minutes – 2018/3/9
IARC Meeting 6 Minutes – 2018/3/2
IARC Meeting 5 Minutes – 2018/2/16
IARC Meeting 4 Minutes – 2018/2/2
IARC Meeting 3 Minutes – 2018/1/26
IARC Meeting 2 Minutes – 2018/1/19
IARC Meeting 1 Minutes – 2018/1/12
