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You are here: Home / The AIRR Community / AIRR Community Sub-committees / Inferred Allele Review Sub-committee (IARC)

Inferred Allele Review Sub-committee (IARC)

Purpose:

The Inferred Allele Review Sub-committee (IARC) was formed after the third AIRR-Community meeting in Rockville, MD in December 2017. The IARC is responsible for judging the validity of germline immunoglobulin and TCR genes inferred from AIRR-Seq data and advising IMGT and the IUIS/IMGT nomenclature committee of their findings. It also reviews inferred sequences and evidence in support of their existence and makes this data available to the AIRR community and other researchers through the OGRDB database. The work of the committee initially focused on human IGHV germline genes, but it is hoped that work will commence on the evaluation of other germline genes and species. Overall, the IARC aims to generate resources for and advocate for better practice in and understanding of IG and TR annotation and analysis in the community interested in studies of AIRR. 

Achievements:

  • Began collating data for inferred human IGHV alleles from interested researchers, and established a formal submission process. 
  • Developed criteria for the review and acceptance of inferred IGHV alleles.
  • With William Lees and Adrian Shepherd of Birkbeck, University of London, co-developed OGRDB, a public resource for the submission, review and publication of previously unknown receptor germline sequences together with supporting evidence.
    • OGRDB has been integrated with VDJbase to simplify submission of VDJbase inferred alleles.
  •  In its first year of operation, 16 new IGHV alleles were approved by the IARC. All 16 sequences were subsequently given names by IUIS/IMGT Nomenclature Committee, and have been incorporated into the IMGT Reference Directory. 

Further details, including evidence in support of the inferences, can be found at the OGRDB website.

Goals for 2022/23

  • Affirmation of additional novel human IGHV, IGKV, IGLV, and TRV alleles and extension of partial genes
  • Identification of expressed AIRR alleles and publication of human IGV germline allele sets (in collaboration with other WGs)
  • Consolidation of a macaque IG germline set by providing expertise to other WGs/IARCs
  • Consolidation of the use of temporary labels in instances where formal gene assignment of alleles cannot be made with confidence (in collaboration with other WGs)
  • Further integration of genomic and transcriptomic data of genes and alleles of IG loci
  • Establishment of processes for allele submission and germline gene sets of other species to OGRDB (in collaboration with other WGs)
  • Submission of manuscript(s) on novel alleles and IARC processes
  • Publication of guidelines for the generation and growth of germline sets to establish formally recognized gene sets
  • Establishment of funding mechanisms moving forward
  • Consolidation of the human TCR IARC process
  • Development IARC sustainability.

Members:

Co-leader: Mats Ohlin

Members: Andrew Collins, Martin Corcoran, James Heather, William Lees, Mats Ohlin (Co-lead), Ayelet Peres, Corey Watson and Gur Yaari. 

Products:

  • 9 inferred immunoglobulin alleles submitted to and approved by IUIS
  • A published commentary on the use of short read sequencing for AIRR allele discovery
  • A submitted manuscript on Balb/c germline alleles identified by inference (co-authored with other WGs)
  • Germline gene sets for Balb/c and C57BL/6 mouse strains published on OGRDB

Related Resources:

The OGRDB database documents the evaluation process of each submitted gene sequence, and provides access to evidence in support of affirmed inferences. 

The VDJbase database of genotypes and haplotypes is being developed in association with OGRDB, and provides evidence of the expression of germline genes in hundreds of individuals.

Discussion of some issues arising from activities of the Germline Database Working Group can be found at the B-T.CR Wiki.

Contact: iarc@airr-community.org

Meeting Minutes

2022:

  • IARC Meeting 99 Minutes – 2022/05/09
  • IARC Meeting 98 Minutes – 2022/04/19
  • IARC Meeting 97 Minutes – 2022/04/11
  • IARC Meeting 96 Minutes – 2022/03/28
  • IARC Meeting 95 Minutes – 2022/03/14
  • IARC Meeting 94 Minutes – 2022/02/28
  • IARC Meeting 93 Minutes – 2022/02/07
  • IARC Meeting 92 Minutes – 2022/01/24
  • IARC Meeting 91 Minutes – 2022/01/10

Archives:

  • 2021
  • 2020
  • 2019
  • 2018

AIRR Community News

AIRR Data Commons and iReceptor Science Gateway Start Major Collaboration with Type-1 Diabetes Researchers

January 11, 2023 By Pam Borghardt

The AIRR Community is pleased to announce the addition of a new Type 1 Diabetes (T1D) focused repository in the AIRR Data Commons. This is a collaboration between the iReceptor team (Simon Fraser University), The Sugar Science group, the Aaron Michels Lab (University of Colorado), and the Todd Brusko Lab (University of Florida) among others. This repository contains the first fully HLA/MHC […]

On AIRR Podcast Episode 10 Now Available!

December 30, 2022 By Pam Borghardt

A new episode of #OnAIRR – the podcast of the AIRR Community is now available. Prof Ralf Küppers, @UniklinikEssen, Germany discusses AIRR-Seq in understanding B cell lymphomas. Building upon Ralf’s background in B cell differentiation in health and pathogenesis of human B cell lymphomas, we discuss how micro-dissection and Sanger sequencing is still the method […]

AIRR-C WG/SC Calls

All times are in ET (Americas/New York)

Click here for full calendar view

BCF23 - Registration Deadline
Mon, January 30, 2023
Call - ComRepo
10:00
Thu, February 2, 2023
Call - Diagnostics WG
11:00
Tue, February 14, 2023
Call - Exec SC
11:00
Thu, February 16, 2023
Call - Standards
14:00
Mon, February 20, 2023

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The Official Journal of The Antibody Society

Recent AIRR Publications

  • Trück J et al, Biological controls for standardization and interpretation of adaptive immune receptor repertoire profiling (eLife, 2021)
  • Arnaout RA, Prak ETL, Schwab N, Rubelt F. Adaptive Immune Receptor Repertoire Community. The Future of Blood Testing Is the Immunome. (Frontiers in Immunology, 2021).

 
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