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You are here: Home / The AIRR Community / AIRR Community Sub-committees / Inferred Allele Review Sub-committee (IARC)

Inferred Allele Review Sub-committee (IARC)

Purpose:

The Inferred Allele Review Sub-committee (IARC) was formed after the third AIRR-Community meeting in Rockville, MD in December 2017. The IARC is responsible for judging the validity of germline immunoglobulin and TCR genes, inferred from RepSeq data. It advises IMGT and the IUIS/IMGT nomenclature committee of their findings. It also reviews inferred sequences, and evidence in support of their existence, and makes this data available to the AIRR community and other researchers through the OGRDB database. The work of the committee initially focused on human IGHV germline genes, but it is hoped that work will commence on the evaluation of other germline genes, and species.

Achievements:

  • Begun collating data for inferred human IGHV alleles from interested researchers, and established a formal submission process. 
  • Developed criteria for the review and acceptance of inferred IGHV alleles.
  • With William Lees and Adrian Shepherd of Birkbeck, University of London, co-developed OGRDB, a public resource for the submission, review and publication of previously unknown receptor germline sequences together with supporting evidence.
  •  In its first year of operation, 16 new IGHV alleles were approved by the IARC. All 16 sequences were subsequently given names by IUIS/IMGT Nomenclature Committee, and have been incorporated into the IMGT Reference Directory. 

Further details, including evidence in support of the inferences, can be found at the OGRDB website.

Goals for 2021

  • Continue to evaluate human IGH IGK, and IGL inferences
  • Establish a human TCR IARC
  • Establish IARC(s) for non-human species
  • Develop tools and guidelines for the evaluation of the ‘quality’ of submitted datasets
  • Streamline procedures for the submission and assessment of human IGHV inferences
  • Develop strategies to make the work of the IARC(s) sustainable

Members:

Co-leader:  Andrew Collins

Members:  Andrew Collins (Co-lead), Martin Corcoran, William Lees, Mats Ohlin, Corey Watson and Gur Yaari. 

Related Resources:

The OGRDB database documents the evaluation process of each submitted gene sequence, and provides access to evidence in support of affirmed inferences. 

The VDJbase database of genotypes and haplotypes is being developed in association with OGRDB, and provides evidence of the expression of germline genes in hundreds of individuals.

Discussion of some issues arising from activities of the Germline Database Working Group can be found at the B-T.CR Wiki.

Contact: iarc@airrc.antibodysociety.org

 

Meeting Minutes:

iARC_Meeting_12_1_18_minutes

iARC_Meeting_19_1_18_minutes

iARC_Meeting_26_1_18_minutes

iARC_Meeting_2_2_18_minutes

iARC Meeting 16_2_18_ minutes

iARC Meeting 2_3_18 minutes

IARC Meeting 7 9_3_18

IARC Meeting 8 19_3_18 minutes

IARC Meeting 9_ 28_3_18_ minutes

IARC Meeting 10_ 6_4_18_ minutes

IARC Meeting 11_ 13_4_18_ minutes

IARC Meeting 12_ 20_4_18_ minutes

IARC Meeting 13_ 2_5_18_ minutes

IARC Meeting 14_ 11_5_18_ minutes

IARC Meeting 15_ 18_5_18_ minutes

IARC Meeting 16_ 25_5_18_ minutes

IARC Meeting 17_ 1_6_18_ minutes

IARC Meeting 18_ 14_6_18_ minutes

IARC Meeting 19_ 19_6_18_ minutes

IARC Meeting 20_ 13_7_18_ minutes

IARC Meeting 21_ 27_7_18_ minutes

IARC Meeting 22_ 10_8_18_ minutes

IARC Meeting 23_ 24_8_18_ minutes

IARC Meeting 24_ 13_9_18_ minutes

IARC Meeting 25_ 28_9_18 minutes

IARC Meeting 26_ 8_11_18 minutes

IARC Meeting 27_ 7_12_18 minutes

Meeting 28_ 21_12_18 minutes

Meeting 29_ 25_1_19 minutes

Meeting 30_ 1_2_19 minutes

Meeting 31_ 8_2_19 minutes

Meeting 32_ 1_3_19 minutes

Meeting 33_ 15_3_19 minutes

Meeting 34_ 29_3_19 minutes

Meeting 35_ 12_4_19 minutes

Meeting 36_ 2_5_19 minutes

Meeting 37_ 31_5_19 minutes

Meeting 38_ 11_6_19 minutes

Meeting 39_ 10_7_19 minutes

Meeting 40_ 7_8_19 minutes

Meeting 41_ 21_8_19 minutes

Meeting 42_ 16_9_19 minutes

Meeting 43_ 7_10_19 minutes

Meeting 44_ 6_11_19 minutes

Meeting 45_ 18_11_19 minutes-1

Meeting 46_ 2_12_19 minutes

Meeting 47_ 9_12_19 minutes

Meeting 48_ 27_1_20 minutes

Meeting 49_ 4_2_20 minutes

Meeting 50_ 24_2_20 minutes

Meeting 58  20_7_20 minutes

Meeting 59 10_8_20 minutes

Meeting 60 1_9_20 minutes

Meeting 61 13_10_20 minutes

Meeting 62 3_11_20 minutes

Meeting 63 24_11_20 minutes

Meeting 64 19_01_21 minutes

Meeting 65 9_02_21 minutes

Meeting 66 8_03_21 minutes

AIRR Community News

Prof. Victor Greiff’s webinar is now available On Demand!

April 5, 2021 By Janice Reichert

In case you missed Prof. Victor Greiff’s very popular webcast on best practices relating to the conception, analysis and performance of adaptive immune receptor repertoire studies, the On Demand version is now online! High-throughput sequencing has enabled the capture of adaptive immune receptor repertoire (AIRR) data at unprecedented depth and precision. This webinar gives an […]

Interns looking for Integrated Immunology Projects

Interns looking for Integrated Immunology Projects

March 6, 2021 By jpburckert

The Friedrich Alexander University in Erlangen (Germany) is looking for PIs working in the AIRR-seq space to take on intern students. The internship should be a short scientific project spanning 8 weeks to 6 months. The application process starts in March and the internship is expected to start in October to December. You can read […]

AIRR-C WG/SC Calls

All times are in ET (Americas/New York)

Click here for full calendar view

BioRes WG - Call
10:00
Wed, April 14, 2021
OntoVoc WG - Call
13:00
Wed, April 14, 2021
Exec SC
11:00
Thu, April 15, 2021
Call - GLDB - Database
16:00
Tue, April 20, 2021
OntoVoc WG - Call
13:00
Wed, April 21, 2021

Recent AIRR Publications

  • Christley et al. “The ADC API: a web API for the programmatic query of the AIRR Data Commons” (Frontiers in Big Data, 2020)
  • Lees et al. “OGRDB: a reference database of inferred immune receptor genes” (Nucleic Acids Research, 2020).

 
See all publications

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