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You are here: Home / The AIRR Community / AIRR Community Working Groups / Germline Database Working Group

Germline Database Working Group

Purpose:

This Working Group (WG) was formed to promote the development of complete and accurate sets of reference germline IG and TCR genes, and to promote the accurate analysis and reporting of the germline genes that can be identified in repertoire studies. The WG works to establish processes for documenting novel germline genes and alleles and standards for versioned, inclusive databases. The WG also provides guidance on specific topics relating to data assessment that may be referred to it by the Inferred Allele Review Sub-committee (IARC).

Goals:

Plans for 2022/23 include:

  • Continuing to develop appropriate IG Reference Sets for human, various mouse strains, and for rhesus macaque, building upon recent efforts by integrating genomic data currently being generated by multiple groups. This integrated effort should result in robust germline sets for these species that could serve as useful models for other non-human organisms.
  • Continuing the development and implementation of the germline database schema.
  • Collaborating with VDJbase to further develop features for cataloguing and sharing non-coding variation.
  • Creating an outreach subgroup to identify academic and commercial partners involved in the generation and use of germline data, as a means to encourage broader inclusion of key stakeholders. Specifically, we want to:
    • Improve the provision of datasets from additional species
    • Identify stakeholders and integrate them into community efforts
    • Promote the uptake of germline sets and schema in tools
    • Develop a plan for sustainability through ongoing funding

Members:

Co-leaders: Jamie Heather and William Lees

Members: Pierre Boudinot, Steven Bosinger, Felix Breden, Christian Busse, Scott Christley, Andrew Collins, Martin Corcoran, Chris Cottrell, Jamie Heather (Co-lead), Gunilla Hedestam, Katherine Jackson, Justin Kos, William Lees (Co-lead), Susana Magadan, Mats Ohlin, Ayelet Peres, Oscar Rodriguez, Cathrine Scheepers, Chaim Schramm, Jamie Scott, Amit Upadhyay, Henk-Jan van den Ham, Corey Watson, Gur Yaari, Jian Ye

Resources:

  • OGRBD: the curated Open Germline Receptor Database
  • VDJbase: a database of adaptive immune receptor germline genotypes and haplotypes
  • Germline Database Working Group Project on the B-T.CR Wiki

Contact: germline-database@airr-community.org

AIRR Community News

On AIRR Podcast Episode 12 Now Available!

May 30, 2023 By Edel Aron

In the latest episode of the On AIRR – An AIRR-C Podcast Series, Dr. Ulrik Stervbo and Dr. Zhaoqing Ding speak with Dr. Charlotte Deane (Professor of Structural Bioinformatics in the Department of Statistics in University of Oxford (UK) and head of the Oxford Protein Informatics Group) about the relevance of including protein structure to […]

On AIRR Podcast Episode 11 Now Available!

May 5, 2023 By Edel Aron

In the latest episode of the On AIRR – An AIRR-C Podcast Series, Dr. Ulrik Stervbo and Dr. Zhaoqing Ding speak with Dr. Xenophon Papademetris (Professor of Radiology and Biomedical Imaging, and Biomedical Engineering at Yale University) about the typical regulatory process for software classified as a medical device. You can subscribe and listen in […]

AIRR-C WG/SC Calls

All times are in ET (Americas/New York)

Click here for full calendar view

Standards WG
14:00
Mon, June 12, 2023
Diagnostics WG
11:00
Tue, June 13, 2023
Executive SC
11:00
Thu, June 15, 2023
Communications SC
12:00
Thu, June 22, 2023
AIRR-C Seminar
10:00
Thu, June 29, 2023

Recent AIRR Publications

Lees W.D. et al. AIRR Community curation and standardised representation for immunoglobulin and T cell receptor germline sets (Immunoinformatics, 2023)

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