The Antibody Society

the official website of the antibody society

The Adaptive Immune Receptor Repertoire Community of The Antibody Society

  • LOG IN
  • BECOME A MEMBER
  • About
    • Mission & Activities
    • Board of Directors
    • Staff & Volunteers
    • The Antibody Society’s Standing Committees
      • Communication & Membership Committee
      • Finance & Audit Committee
      • Initiatives Committee
      • Meetings Committee
    • Advisors
    • Sponsors
    • James S. Huston Antibody Science Talent Award
      • JSH Award Criteria
  • Society meetings
    • Antibody Engineering & Therapeutics (US) 2020
      • 2019 Antibody Engineering & Therapeutics
      • 2018 Antibody Engineering & Therapeutics
      • Meeting reports
      • Keynote presentations
      • What is INN a Name?
        • INN issue updates
    • Antibody Engineering & Therapeutics Europe 2020
      • Antibody Engineering & Therapeutics Europe 2019
    • AIRR Community Meetings
    • FOCIS Symposia
    • Society-Funded Meetings
  • AIRR Community
    • AIRR News
    • AIRR Publications
    • AIRR Meetings
      • AIRR Community Meeting VI: “Exploring New Frontiers”
      • AIRR Community Meeting V: “Zooming in to the AIRR Community”
      • AIRR Community Meeting V Pre-Meetings
        • AIRR-seq in the Pandemic
        • AIRR-seq Biological Standards and Workflows
      • AIRR Community Special Event: “Response to COVID-19”
      • AIRR Community Meeting IV: “Bridging the Gaps”
      • AIRR Community Meeting III
        • Day 1
        • Day 2
        • Day 3
        • Day 4
      • AIRR Community Meeting II
      • AIRR Community Meeting I
    • AIRR Community Working Groups
      • Biological Resources Working Group
      • Common Repository Working Group
      • Data Representation Working Group
      • Diagnostics Working Group
      • Germline Database Working Group
      • Legal and Ethics Working Group
      • Minimal Standards Working Group
      • Software Working Group
    • AIRR Community Sub-committees
      • Communications Sub-committee
      • Executive Sub-committee
      • Inferred Allele Review Committee
      • Meetings Sub-committee
    • AIRR Community Calendar
    • AIRR Community Resources
  • Members only
    • Login
    • Note to members
    • Antibodies in early-stage studies
    • Antibodies in late-stage studies
    • Presentations
  • Upcoming meetings
  • Web Resources
    • Society Publications
    • Antibody News You Should Know
    • Antibody therapeutics approved or in regulatory review in the EU or US
    • Research Resources
    • Education Resources
  • Career Center
  • Learning Center
    • Upcoming Webinars
    • Antibody Discovery & Development
    • Antibodies to Watch
    • Antibody Validation
  • COVID-19
    • Guide to “Coronavirus in the Crosshairs”
    • COVID-19 Biologics Tracker
    • Meeting Report: The Diagnostic Landscape for COVID-19
You are here: Home / The AIRR Community / AIRR Community Working Groups / Germline Database Working Group

Germline Database Working Group

Purpose:

This Working Group (WG) was formed to promote the development of complete and accurate sets of reference germline IG and TCR genes, and to promote the accurate analysis and reporting of the germline genes that can be identified in repertoire studies. The WG works to establish processes for documenting novel germline genes and alleles and standards for versioned, inclusive databases. The WG also provides guidance on specific topics relating to data assessment that may be referred to it by the Inferred Allele Review Sub-committee (IARC). 

Achievements:

  • Finalized a formal process for depositing data associated with inferred novel alleles.
  • Worked with NCBI and IMGT to establish an efficient process for the submission of inferred allele data.
  • Produced a “how-to” manual for the AIRR Community that outlines the submission and review process of inferred novel alleles.

Goals:

Plans for 2019/2020 include:

  • Develop criteria for the review and acceptance of inferred human alleles for other IG and TR loci.
  • Resolve issues relating to GLDBs of mouse, macaque, and salmonid sequences, and establish general principles that can be applied to the development of nomenclatures and databases for non-human species. 
  • Establish guidelines for assessing the robustness of datasets for the inference of germline gene variation.

Members:

Co-leaders: Andrew Collins and Corey Watson

Members: Davide Bagnara, Felix Breden, Jean-Philippe “JP” Bürckert, Christian Busse, Scott Christley, Martin Corcoran, William Gibson, Victor Greiff, Henk-Jan van dan Ham, Jamie Heather, Katherine Jackson, Justin Kos, William Lees, Susana Magadan, Susanna Marquez, Mats Ohlin, Pierre Boudinot, Duncan Ralph, Oscar Rodriguez, Cathrine Scheepers, Chaim Schramm, Jamie Scott, and Gur Yaari.

Resources:

Visit OGRBD, the curated Open Germline Receptor Database.

Visit VDJbase, a database of adaptive immune receptor germline genotypes and haplotypes.  

Visit the Germline Database Working Group Project on the B-T.CR Wiki.

Contact: germlines@airrc.antibodysociety.org

AIRR Community News

Successful AIRR Community Meeting V

January 15, 2021 By Pam Borghardt

The fifth AIRR Community meeting (#AIRRC5) was held virtually Dec 8–10, 2020. The theme of this meeting was “Zooming in to the AIRR Community” connecting the global AIRR research community despite the pandemic for a series of Working Group & Sub-committee presentations, scientific sessions, interactive poster sessions, software tool demonstrations and networking events. AIRR Community […]

AIRR Community and PrecisionFDA COVID-19 Precision Immunology App-a-thon

December 28, 2020 By Pam Borghardt

The AIRR Community is helping to lead the PrecisionFDA COVID-19 Precision Immunology App-a-thon.   This is part of the “precisionFDA Challenges” program, which is designed to engage and improve software that analyzes NGS (next generation sequencing data) through community challenges. There were 68 bioinformaticians pre-registered for the Precision Immunology Challenge, and more are expected to join […]

AIRR-C WG/SC Calls

All times are in ET (Americas/New York)

Click here for full calendar view

ComRepo WG - Call
10:00
Thu, January 28, 2021
Meetings SC
10:30
Tue, February 2, 2021
BioRes WG - Call
10:00
Wed, February 3, 2021
Standards WG - Call
14:00
Mon, February 8, 2021
Exec SC w. Co-leads
11:00
Tue, February 16, 2021

Recent AIRR Publications

  • Christley et al. “The ADC API: a web API for the programmatic query of the AIRR Data Commons” (Frontiers in Big Data, 2020)
  • Lees et al. “OGRDB: a reference database of inferred immune receptor genes” (Nucleic Acids Research, 2020).

 
See all publications

Archives

Follow Us Online

  • Email
  • LinkedIn
  • Twitter
  • YouTube
  • Slack
  • Home
  • Privacy & Terms of Use
  • About
  • Board of Directors
  • Advisors
  • Sponsors
  • Mission & Activities
  • Join the Society
  • Membership Levels
  • Members only
  • Login
  • Antibody therapeutics approved or in regulatory review in the EU or US
  • Meeting reports
  • Presentations
  • Contact

©2015 - scicomvisuals