Purpose:
This Working Group (WG) was formed to promote the development of complete and accurate sets of reference germline IG and TCR genes, and to promote the accurate analysis and reporting of the germline genes that can be identified in repertoire studies. The WG works to establish processes for documenting novel germline genes and alleles and standards for versioned, inclusive databases. The WG also provides guidance on specific topics relating to data assessment that may be referred to it by the Inferred Allele Review Sub-committee (IARC).
Achievements:
- Finalized a formal process for depositing data associated with inferred novel alleles.
- Worked with NCBI and IMGT to establish an efficient process for the submission of inferred allele data.
- Produced a “how-to” manual for the AIRR Community that outlines the submission and review process of inferred novel alleles.
Goals:
Plans for 2019/2020 include:
- Develop criteria for the review and acceptance of inferred human alleles for other IG and TR loci.
- Resolve issues relating to GLDBs of mouse, macaque, and salmonid sequences, and establish general principles that can be applied to the development of nomenclatures and databases for non-human species.
- Establish guidelines for assessing the robustness of datasets for the inference of germline gene variation.
Members:
Co-leaders: Andrew Collins and Corey Watson
Members: Davide Bagnara, Felix Breden, Jean-Philippe “JP” Bürckert, Christian Busse, Scott Christley, Martin Corcoran, William Gibson, Victor Greiff, Henk-Jan van dan Ham, Jamie Heather, Katherine Jackson, Justin Kos, William Lees, Susana Magadan, Susanna Marquez, Mats Ohlin, Pierre Boudinot, Duncan Ralph, Oscar Rodriguez, Cathrine Scheepers, Chaim Schramm, Jamie Scott, and Gur Yaari.
Resources:
Visit OGRBD, the curated Open Germline Receptor Database.
Visit VDJbase, a database of adaptive immune receptor germline genotypes and haplotypes.
Visit the Germline Database Working Group Project on the B-T.CR Wiki.
