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You are here: Home / The AIRR Community / AIRR Community Working Groups / Germline Database Working Group

Germline Database Working Group

Purpose:

This Working Group (WG) was formed to promote the development of complete and accurate sets of reference germline IG and TCR genes, and to promote the accurate analysis and reporting of the germline genes that can be identified in repertoire studies. The WG works to establish processes for documenting novel germline genes and alleles and standards for versioned, inclusive databases. The WG also provides guidance on specific topics relating to data assessment that may be referred to it by the Inferred Allele Review Sub-committee (IARC).

Goals:

Plans for 2022/23 include:

  • Continuing to develop appropriate IG Reference Sets for human, various mouse strains, and for rhesus macaque, building upon recent efforts by integrating genomic data currently being generated by multiple groups. This integrated effort should result in robust germline sets for these species that could serve as useful models for other non-human organisms.
  • Continuing the development and implementation of the germline database schema.
  • Collaborating with VDJbase to further develop features for cataloguing and sharing non-coding variation.
  • Creating an outreach subgroup to identify academic and commercial partners involved in the generation and use of germline data, as a means to encourage broader inclusion of key stakeholders. Specifically, we want to:
    • Improve the provision of datasets from additional species
    • Identify stakeholders and integrate them into community efforts
    • Promote the uptake of germline sets and schema in tools
    • Develop a plan for sustainability through ongoing funding

Members:

Co-leaders: Jamie Heather and William Lees

Members: Pierre Boudinot, Steven Bosinger, Felix Breden, Christian Busse, Scott Christley, Andrew Collins, Martin Corcoran, Chris Cottrell, Jamie Heather (Co-lead), Gunilla Hedestam, Katherine Jackson, Justin Kos, William Lees (Co-lead), Susana Magadan, Mats Ohlin, Ayelet Peres, Oscar Rodriguez, Cathrine Scheepers, Chaim Schramm, Jamie Scott, Amit Upadhyay, Henk-Jan van den Ham, Corey Watson, Gur Yaari, Jian Ye

Resources:

  • OGRBD: the curated Open Germline Receptor Database
  • VDJbase: a database of adaptive immune receptor germline genotypes and haplotypes
  • Germline Database Working Group Project on the B-T.CR Wiki

Contact: germline-database@airr-community.org

AIRR Community News

AIRR Data Commons and iReceptor Science Gateway Start Major Collaboration with Type-1 Diabetes Researchers

January 11, 2023 By Pam Borghardt

The AIRR Community is pleased to announce the addition of a new Type 1 Diabetes (T1D) focused repository in the AIRR Data Commons. This is a collaboration between the iReceptor team (Simon Fraser University), The Sugar Science group, the Aaron Michels Lab (University of Colorado), and the Todd Brusko Lab (University of Florida) among others. This repository contains the first fully HLA/MHC […]

On AIRR Podcast Episode 10 Now Available!

December 30, 2022 By Pam Borghardt

A new episode of #OnAIRR – the podcast of the AIRR Community is now available. Prof Ralf Küppers, @UniklinikEssen, Germany discusses AIRR-Seq in understanding B cell lymphomas. Building upon Ralf’s background in B cell differentiation in health and pathogenesis of human B cell lymphomas, we discuss how micro-dissection and Sanger sequencing is still the method […]

AIRR-C WG/SC Calls

All times are in ET (Americas/New York)

Click here for full calendar view

BCF23 - Registration Deadline
Mon, January 30, 2023
Call - ComRepo
10:00
Thu, February 2, 2023
Call - Diagnostics WG
11:00
Tue, February 14, 2023
Call - Exec SC
11:00
Thu, February 16, 2023
Call - Standards
14:00
Mon, February 20, 2023

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The Official Journal of The Antibody Society

Recent AIRR Publications

  • Trück J et al, Biological controls for standardization and interpretation of adaptive immune receptor repertoire profiling (eLife, 2021)
  • Arnaout RA, Prak ETL, Schwab N, Rubelt F. Adaptive Immune Receptor Repertoire Community. The Future of Blood Testing Is the Immunome. (Frontiers in Immunology, 2021).

 
See all publications

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