The Antibody Society

the official website of the antibody society

The Adaptive Immune Receptor Repertoire Community of The Antibody Society

  • LOG IN
  • BECOME A MEMBER
  • About
    • Mission & Activities
    • Directors and Officers
    • The Antibody Society’s Committees
      • AIRR Community Committee
      • Communication & Membership Committee
      • Meetings Committee
    • Sponsors & Partners
  • Society meetings
    • Harnessing Cytokines for Cancer Immunotherapy Symposium
    • Biopharmaceutical Informatics Symposium
    • Emerging Cancer Therapies Leveraging Gamma-Delta Effector T cells Symposium
    • Emerging Immunotherapeutics for Ovarian Cancer Symposium
    • AIRR Community Meetings
    • Antibody Engineering & Therapeutics (US) 2023
      • 2022 Antibody Engineering & Therapeutics
      • 2020 Antibody Engineering & Therapeutics
      • 2019 Antibody Engineering & Therapeutics
      • 2018 Antibody Engineering & Therapeutics
      • What is INN a Name?
        • INN issue updates
    • Antibody Engineering & Therapeutics Europe 2023
    • FOCIS Symposia
  • AIRR Community
    • AIRR News
    • AIRR Publications
    • AIRR Meetings
      • AIRR Community Meeting VI: “Exploring New Frontiers”
      • AIRR Community Meeting V: “Zooming in to the AIRR Community”
      • AIRR Community Meeting V Pre-Meetings
        • AIRR-seq in the Pandemic
        • AIRR-seq Biological Standards and Workflows
      • AIRR Community Special Event: “Response to COVID-19”
      • AIRR Community Meeting IV: “Bridging the Gaps”
      • AIRR Community Meeting III
        • Day 1
        • Day 2
        • Day 3
        • Day 4
      • AIRR Community Meeting II
      • AIRR Community Meeting I
    • AIRR Community Working Groups
      • Biological Resources Working Group
      • Common Repository Working Group
      • Diagnostics Working Group
      • Germline Database Working Group
      • Legal and Ethics Working Group
      • Software Working Group
      • Standards Working Group
    • AIRR Community Sub-committees
      • Communications Sub-committee
      • Executive Sub-committee
      • Inferred Allele Review Committee
      • Meetings Sub-committee
    • AIRR Data Commons
    • AIRR Community Calendar
    • AIRR Community Webinar Series
    • On AIRR – An AIRR Community Podcast
    • AIRR Community Resources
    • AIRR Community Service Prize 2022
  • Members only
    • Login
    • Note to members
    • James S. Huston Antibody Science Talent Award
      • 2021 James S. Huston Antibody Science Talent Award Recipient
      • 2020 James S. Huston Antibody Science Talent Award Recipient
      • JSH Award Criteria
    • Science Writing Competition
      • Science Writing Competition Winners
    • Imaging Competition
    • Research Competitions
      • Research Competition Winners
    • Member discount codes
    • Antibodies in early-stage studies
    • Presentations
  • Upcoming meetings
  • Web Resources
    • Society Publications
    • Antibody News
    • Antibody therapeutics approved or in regulatory review in the EU or US
      • Antibody therapeutics product data
    • Antibodies in late-stage clinical studies
    • Research Resources
    • Education Resources
  • Career Center
    • Career Shorts
  • Learning Center
    • Upcoming Webinars
    • Snakebite antivenoms: Global challenges and progress toward recombinant antibody therapeutics
    • Adaptive Immune Receptor Repertoires
    • Antibody Discovery & Development
    • Commercializing Antibody Therapeutics
    • Antibodies to Watch
    • Antibody Validation
  • COVID-19
    • Guide to “Coronavirus in the Crosshairs”
    • COVID-19 Biologics Tracker
    • Meeting Report: The Diagnostic Landscape for COVID-19
You are here: Home / The AIRR Community / AIRR Community Working Groups / Diagnostics Working Group

Diagnostics Working Group

Purpose:

To advance AIRR-seq for clinical use, i.e. in prognosis, diagnostics, and disease monitoring. The working group strives to uncover why there has been little translation of the tremendous progress in the field of AIRR-seq into the clinics. Furthermore, the working group aims to identify and promote ways of expanding AIRR-seq techniques into general clinical use. This covers both sequencing technologies and analytical methods and will be achieved through:

  • Evaluation of the usage of AIRR-seq data for diagnostic purposes. These include diagnosis, prognosis, monitoring purposes, inclusion biomarkers for clinical studies, etc.
  • Identification of bottlenecks or challenges for AIRR-seq based clinical assays. These can be software tools, but also data sets or general approaches such as statistical methods, machine learning, pattern recognition, etc.

Plans for 2022/23 include:

  • Engagement of key opinion leaders to uncover barriers in translating progress in AIRR-seq into the clinic
  • Broadly disseminating the existing and potential possibilities for AIRR-seq in the clinic
  • Engagement  of regulatory bodies (e.g. FDA) to create strategies to overcome obstacles in bringing AIRR-seq into the clinic
  • Production and extension of the reach of additional episodes of the podcast “onAIRR” through support and and direct contribution
  • Plan and hold a single meeting with diagnostics as a focal point, with support of the AIRR-C Communications SC, Legal and Ethics WG, and Meetings SC.
  • Promotion of the working group at IUIS 2023 and/or FOCIS June 2023
  • Coordinate a white paper to regulatory bodies with the working groups opinion on how to best include AIRR-seq in regulatory processes.

Long-term vision and how WG or SC products integrate with the AIRR-C mission: 

  • Promoting the vision described in our perspective paper The Future of Blood Testing Is the Immunome (Front. Immunol., 15 March 2021) through community outreach and engagement
  • Promoting adoption of the standards established in the Standards Working Group for a common framework for clinical classifier discovery
  • Acting as an umbrella for clinic-oriented members of various AIRR-C working groups, such as the Biological Resources, Legal and Ethics and Software Working Groups, to brainstorm and promote further development and applications of AIRR-seq clinical testing (e.g. potential project design, standard data collection, software tools, extension to new diseases or uses)
  • Representing a link between the AIRR-seq community and regulatory agencies regarding clinical application of AIRR-Seq

Members:

Co-leaders: Susanna Marquez and Ulrik Stervbo

Members: Rohit Arora, Lmar Babrak, Rachael Bashford-Rogers, Magnolia Bostick, Felix Breden, Syed Ahmad Chan Bukhari, Brian Corrie, Lindsay Cowell, Sol Efroni, Khalil El Mazouari, Christopher Gooley , Victor Greiff, David Klatzmann, Yoshinobu Koguchi, Ton Langerak, Theam Soon  Lim, Eline Luning Prak, Susanna Marquez (Co-lead), Pieter Meysman, Enkelejda Miho, Nima Nouri, Milena Pavlović, Florian Rubelt, Geir Kjetil Sandve, Tilman Schneider-Hohendorf, Nicholas Schwab , Erand Smakaj, Cinque Soto, Ulrik Stervbo (Co-lead), Johannes Trück, Henk-Jan van den Ham, Eric Waltari, and Corey Watson

Contact: diagnostics@airr-community.org

Products:

  • Podcast
  • The Future of Blood Testing Is the Immunome (Front. Immunol., 15 March 2021)
  • Contributions to Immunogenetics: Methods and Protocols, Methods in Molecular Biology, In press.
  • Contributions to data sets shared in the AIRR Data Commons (COVID-19)

 

AIRR Community News

AIRR Data Commons and iReceptor Science Gateway Start Major Collaboration with Type-1 Diabetes Researchers

January 11, 2023 By Pam Borghardt

The AIRR Community is pleased to announce the addition of a new Type 1 Diabetes (T1D) focused repository in the AIRR Data Commons. This is a collaboration between the iReceptor team (Simon Fraser University), The Sugar Science group, the Aaron Michels Lab (University of Colorado), and the Todd Brusko Lab (University of Florida) among others. This repository contains the first fully HLA/MHC […]

On AIRR Podcast Episode 10 Now Available!

December 30, 2022 By Pam Borghardt

A new episode of #OnAIRR – the podcast of the AIRR Community is now available. Prof Ralf Küppers, @UniklinikEssen, Germany discusses AIRR-Seq in understanding B cell lymphomas. Building upon Ralf’s background in B cell differentiation in health and pathogenesis of human B cell lymphomas, we discuss how micro-dissection and Sanger sequencing is still the method […]

AIRR-C WG/SC Calls

All times are in ET (Americas/New York)

Click here for full calendar view

BCF23 - Registration Deadline
Mon, January 30, 2023
Call - ComRepo
10:00
Thu, February 2, 2023
Call - Diagnostics WG
11:00
Tue, February 14, 2023
Call - Exec SC
11:00
Thu, February 16, 2023
Call - Standards
14:00
Mon, February 20, 2023

mabs

mabs

The Official Journal of The Antibody Society

Recent AIRR Publications

  • Trück J et al, Biological controls for standardization and interpretation of adaptive immune receptor repertoire profiling (eLife, 2021)
  • Arnaout RA, Prak ETL, Schwab N, Rubelt F. Adaptive Immune Receptor Repertoire Community. The Future of Blood Testing Is the Immunome. (Frontiers in Immunology, 2021).

 
See all publications

Archives

Follow Us Online

  • Email
  • LinkedIn
  • Twitter
  • YouTube
  • Slack
  • Home
  • Privacy & Terms of Use
  • About
  • Directors and Officers
  • Advisors
  • Sponsors & Partners
  • Mission & Activities
  • Join the Society
  • Membership Levels
  • Members only
  • Login
  • Antibody therapeutics approved or in regulatory review in the EU or US
  • Meeting reports
  • Presentations
  • Contact

©2015 - scicomvisuals