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You are here: Home / The AIRR Community / AIRR Community Working Groups / Biological Resources Working Group

Biological Resources Working Group

Purpose:

To provide the AIRR Community with biological calibrators and reagents for evaluation of AIRR-seq.

The Biological Resources Working Group is responsible for coordinating the development of reference samples that can be used as controls. The working group aims at reaching out to established organizations such as NIST and Genome in a Bottle, as well as companies to help encourage ease of use and broad adoption.

Goals:

The goal of the working group is to be able to provide AIRR biological standards and protocol recommendations to the scientific and biomedical community. Recommendation of a set of biological standards that can be used for normalization of data sets will allow more direct comparison of data generated by different library prep methods.

Plans for 2022/23 include:

  • Generation of data from different BCR sequencing methods using three different types of standards: synthetic RNA templates, spleen DNA/RNA and cell line mixtures
  • Generation of data from TCR sequencing standards comparison, starting from the methods that performed best in the Nature Biotechnology publication that was led by several of the WG members (Barennes et al., 2021)
  • Continued participation in FDA BCR-SEQC initiative
  • Continued participation in EuroClonality WG and meetings
  • Generation of data and publication of a paper about sequencing depth and sample optimization for unique molecular identifiers (UMIs)

Long term:

  • Evaluate products
  • Outreach to academic and commercial partners
  • Produce and share selected calibrators and reagents
  • Labs/protocols for production
  • Legal agreements for distribution
  • Lab survey on standard B cell and T cell samples, including calibrators (MiAIRR data compliant)
  • Define statistical measures (in collaboration with other WGs)

Products:

  • Validated reagents
  • Publication: review on existing reagents and application
  • Publication in eLife (Trück et al., 2021)

Members:

Co-leaders: Anne Eugster, Nina Luning Prak and Johannes Trück

Members: Houda Alachkar, Davide Bagnara, John Beckford, Anne Eugster (Co-lead), Nina Luning Prak (Co-lead), Encarnita Mariotti-Ferrandiz, Johannes Trück (Co-lead), Nidhi Gupta, Andrew Farmer, Shaveta Goyal, Theam Soon Lim, Wenming Xiao.

Contact: biological-resources@airr-community.org

AIRR Community News

AIRR Data Commons and iReceptor Science Gateway Start Major Collaboration with Type-1 Diabetes Researchers

January 11, 2023 By Pam Borghardt

The AIRR Community is pleased to announce the addition of a new Type 1 Diabetes (T1D) focused repository in the AIRR Data Commons. This is a collaboration between the iReceptor team (Simon Fraser University), The Sugar Science group, the Aaron Michels Lab (University of Colorado), and the Todd Brusko Lab (University of Florida) among others. This repository contains the first fully HLA/MHC […]

On AIRR Podcast Episode 10 Now Available!

December 30, 2022 By Pam Borghardt

A new episode of #OnAIRR – the podcast of the AIRR Community is now available. Prof Ralf Küppers, @UniklinikEssen, Germany discusses AIRR-Seq in understanding B cell lymphomas. Building upon Ralf’s background in B cell differentiation in health and pathogenesis of human B cell lymphomas, we discuss how micro-dissection and Sanger sequencing is still the method […]

AIRR-C WG/SC Calls

All times are in ET (Americas/New York)

Click here for full calendar view

BCF23 - Registration Deadline
Mon, January 30, 2023
Call - ComRepo
10:00
Thu, February 2, 2023
Call - Diagnostics WG
11:00
Tue, February 14, 2023
Call - Exec SC
11:00
Thu, February 16, 2023
Call - Standards
14:00
Mon, February 20, 2023

mabs

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The Official Journal of The Antibody Society

Recent AIRR Publications

  • Trück J et al, Biological controls for standardization and interpretation of adaptive immune receptor repertoire profiling (eLife, 2021)
  • Arnaout RA, Prak ETL, Schwab N, Rubelt F. Adaptive Immune Receptor Repertoire Community. The Future of Blood Testing Is the Immunome. (Frontiers in Immunology, 2021).

 
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