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You are here: Home / The AIRR Community / AIRR Community Working Groups / Biological Resources Working Group

Biological Resources Working Group

Purpose:

To provide the AIRR Community with biological calibrators and reagents for evaluation of AIRR-seq. 

The Biological Resources Working Group is responsible for coordinating the development of reference samples that can be used as controls. The working group will reach out to established organizations such as NIST and Genome in a Bottle, as well as companies like ATCC and Novartis to help encourage ease of use and broad adoption.

Goals:

The goal of the working group is to be able to recommend a set of biological standards that can be used for normalization of data sets. This will allow more direct comparison of data generated by different library prep methods. Ultimately they would like to have DNA and RNA spike-ins, in addition to cell mixes that can be used for this purpose.

Plans for 2019/2020 include:

  • Submit a manuscript reviewing biological standards and other analytical controls for immune repertoire profiling experiments by NGS
  • Identify the prioritized control and critical application(s) thereof (also, if we are creating a brand new standard, we need to consider funding applications)
  • Develop a proposal for industry (Takarabio as the first target) with a value proposition for production and testing of the control.

Long term:

  • Evaluate products
  • Outreach to academic and commercial partners
  • Produce and share selected calibrators and reagents
  • Labs/protocols for production
  • Legal agreements for distribution
  • Lab survey on standard B cell and T cell samples, including calibrators (MiAIRR data compliant)
  • Define statistical measures (in collaboration with other WGs)

Products:

  • Validated reagents
  • Publication: review on existing reagents and application

 

Members:

Co-leaders: Maggie Bostick and Encarnita Mariotti-Ferrandiz

Members: Francisco Arcila, Davide Bagnara, Pierre Bareness, Maggie Bostick (Co-lead), Christian Busse, Elaine Chen, Lindsay Cowell, Anne Eugster, Marie Paule Lefranc, Nina Luning Prak, Encarnita Mariotti-Ferrandiz (Co-lead), Aimee Payne, Jacob Sherkow, Hye-Won Song, Cinque Soto,  Chris Tipton,  Johannes Trüeck, and Ian York.

Contact: bioresources@airrc.antibodysociety.org

AIRR Community News

Successful AIRR Community Meeting V

January 15, 2021 By Pam Borghardt

The fifth AIRR Community meeting (#AIRRC5) was held virtually Dec 8–10, 2020. The theme of this meeting was “Zooming in to the AIRR Community” connecting the global AIRR research community despite the pandemic for a series of Working Group & Sub-committee presentations, scientific sessions, interactive poster sessions, software tool demonstrations and networking events. AIRR Community […]

AIRR Community and PrecisionFDA COVID-19 Precision Immunology App-a-thon

December 28, 2020 By Pam Borghardt

The AIRR Community is helping to lead the PrecisionFDA COVID-19 Precision Immunology App-a-thon.   This is part of the “precisionFDA Challenges” program, which is designed to engage and improve software that analyzes NGS (next generation sequencing data) through community challenges. There were 68 bioinformaticians pre-registered for the Precision Immunology Challenge, and more are expected to join […]

AIRR-C WG/SC Calls

All times are in ET (Americas/New York)

Click here for full calendar view

ComRepo WG - Call
10:00
Thu, January 28, 2021
Meetings SC
10:30
Tue, February 2, 2021
BioRes WG - Call
10:00
Wed, February 3, 2021
Standards WG - Call
14:00
Mon, February 8, 2021
Exec SC w. Co-leads
11:00
Tue, February 16, 2021

Recent AIRR Publications

  • Christley et al. “The ADC API: a web API for the programmatic query of the AIRR Data Commons” (Frontiers in Big Data, 2020)
  • Lees et al. “OGRDB: a reference database of inferred immune receptor genes” (Nucleic Acids Research, 2020).

 
See all publications

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