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You are here: Home / The AIRR Community / AIRR Community Working Groups / Biological Resources Working Group

Biological Resources Working Group

Purpose:

To provide the AIRR Community with biological calibrators and reagents for evaluation of AIRR-seq.

The Biological Resources Working Group is responsible for coordinating the development of reference samples that can be used as controls. The working group aims at reaching out to established organizations such as NIST and Genome in a Bottle, as well as companies to help encourage ease of use and broad adoption.

Goals:

The goal of the working group is to be able to provide AIRR biological standards and protocol recommendations to the scientific and biomedical community. Recommendation of a set of biological standards that can be used for normalization of data sets will allow more direct comparison of data generated by different library prep methods.

Plans for 2022/23 include:

  • Generation of data from different BCR sequencing methods using three different types of standards: synthetic RNA templates, spleen DNA/RNA and cell line mixtures
  • Generation of data from TCR sequencing standards comparison, starting from the methods that performed best in the Nature Biotechnology publication that was led by several of the WG members (Barennes et al., 2021)
  • Continued participation in FDA BCR-SEQC initiative
  • Continued participation in EuroClonality WG and meetings
  • Generation of data and publication of a paper about sequencing depth and sample optimization for unique molecular identifiers (UMIs)

Long term:

  • Evaluate products
  • Outreach to academic and commercial partners
  • Produce and share selected calibrators and reagents
  • Labs/protocols for production
  • Legal agreements for distribution
  • Lab survey on standard B cell and T cell samples, including calibrators (MiAIRR data compliant)
  • Define statistical measures (in collaboration with other WGs)

Products:

  • Validated reagents
  • Publication: review on existing reagents and application
  • Publication in eLife (Trück et al., 2021)

Members:

Co-leaders: Anne Eugster, Nina Luning Prak and Johannes Trück

Members: Houda Alachkar, Davide Bagnara, John Beckford, Anne Eugster (Co-lead), Nina Luning Prak (Co-lead), Encarnita Mariotti-Ferrandiz, Johannes Trück (Co-lead), Nidhi Gupta, Andrew Farmer, Shaveta Goyal, Theam Soon Lim, Wenming Xiao.

Contact: biological-resources@airr-community.org

AIRR Community News

On AIRR Podcast Episode 12 Now Available!

May 30, 2023 By Edel Aron

In the latest episode of the On AIRR – An AIRR-C Podcast Series, Dr. Ulrik Stervbo and Dr. Zhaoqing Ding speak with Dr. Charlotte Deane (Professor of Structural Bioinformatics in the Department of Statistics in University of Oxford (UK) and head of the Oxford Protein Informatics Group) about the relevance of including protein structure to […]

On AIRR Podcast Episode 11 Now Available!

May 5, 2023 By Edel Aron

In the latest episode of the On AIRR – An AIRR-C Podcast Series, Dr. Ulrik Stervbo and Dr. Zhaoqing Ding speak with Dr. Xenophon Papademetris (Professor of Radiology and Biomedical Imaging, and Biomedical Engineering at Yale University) about the typical regulatory process for software classified as a medical device. You can subscribe and listen in […]

AIRR-C WG/SC Calls

All times are in ET (Americas/New York)

Click here for full calendar view

Standards WG
14:00
Mon, June 12, 2023
Diagnostics WG
11:00
Tue, June 13, 2023
Executive SC
11:00
Thu, June 15, 2023
Communications SC
12:00
Thu, June 22, 2023
AIRR-C Seminar
10:00
Thu, June 29, 2023

Recent AIRR Publications

Lees W.D. et al. AIRR Community curation and standardised representation for immunoglobulin and T cell receptor germline sets (Immunoinformatics, 2023)

See all publications

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