The Antibody Society

the official website of the antibody society

The Adaptive Immune Receptor Repertoire Community of The Antibody Society

  • LOG IN
  • BECOME A MEMBER
  • About
    • Mission & Activities
    • Directors and Officers
    • The Antibody Society’s Committees
      • Communication & Membership Committee
      • Meetings Committee
      • AIRR Community Working Groups & Subcommittees
    • Sponsors & Partners
  • Society meetings
    • Computational Antibody Discovery: State of the Art
      • Computational Antibody Discovery Symposium Participants
    • Harnessing Cytokines for Cancer Immunotherapy Symposium
    • Biopharmaceutical Informatics Symposium
    • Emerging Cancer Therapies Leveraging Gamma-Delta Effector T cells Symposium
    • Emerging Immunotherapeutics for Ovarian Cancer Symposium
    • AIRR Community Meetings
    • Antibody Engineering & Therapeutics (US) 2023
      • 2022 Antibody Engineering & Therapeutics
      • 2020 Antibody Engineering & Therapeutics
      • 2019 Antibody Engineering & Therapeutics
      • 2018 Antibody Engineering & Therapeutics
      • What is INN a Name?
        • INN issue updates
    • Antibody Engineering & Therapeutics Europe 2023
      • Scientific Advisors, Antibody Engineering & Therapeutics Europe
    • FOCIS Symposia
  • AIRR Community
    • AIRR News
    • AIRR Community Seminar Series
    • AIRR Publications
    • AIRR Meetings
      • AIRR Community Meeting VII – Learnings and Perspectives
      • AIRR Community Special Event 2023  – Zooming in to the Community II
      • AIRR Community Meeting VI: “Exploring New Frontiers”
      • AIRR Community Meeting V: “Zooming in to the AIRR Community”
      • AIRR Community Meeting V Pre-Meetings
        • AIRR-seq in the Pandemic
        • AIRR-seq Biological Standards and Workflows
      • AIRR Community Special Event: “Response to COVID-19”
      • AIRR Community Meeting IV: “Bridging the Gaps”
      • AIRR Community Meeting III
        • Day 1
        • Day 2
        • Day 3
        • Day 4
      • AIRR Community Meeting II
      • AIRR Community Meeting I
    • AIRR Community Working Groups
      • Biological Resources Working Group
      • Common Repository Working Group
      • Diagnostics Working Group
      • Germline Database Working Group
      • Legal and Ethics Working Group
      • Software Working Group
      • Standards Working Group
    • AIRR Community Sub-committees
      • Communications Sub-committee
      • Executive Sub-committee
      • Inferred Allele Review Committee
      • Meetings Sub-committee
      • Strategic Planning Sub-Committee
    • AIRR Data Commons
    • AIRR Community Calendar
    • AIRR Community Webinar Series
    • On AIRR – An AIRR Community Podcast
    • AIRR Community Resources
    • AIRR Community Service Prize 2022
  • Members only
    • Login
    • Note to members
    • Member discount codes
    • 2023 Calendar of Events
    • James S. Huston Antibody Science Talent Award
      • 2021 James S. Huston Antibody Science Talent Award Recipient
      • 2020 James S. Huston Antibody Science Talent Award Recipient
      • Huston Award Criteria
    • Science Writing Competition
      • Science Writing Competition Winners
    • Imaging Competition
      • Imaging Calendar Competition winners
    • Research Competitions
      • Research Competition Winners
    • Antibodies in early-stage studies
    • Presentations
  • Upcoming meetings
  • Web Resources
    • Society Publications
    • Antibody News
    • Antibody therapeutics approved or in regulatory review in the EU or US
      • Antibody therapeutics product data
    • Antibodies in late-stage clinical studies
    • Research Resources
    • Education Resources
  • Career Center
    • Career Shorts
  • Learning Center
    • Upcoming Webinars
    • Snakebite antivenoms: Global challenges and progress toward recombinant antibody therapeutics
    • Adaptive Immune Receptor Repertoires
    • Antibody Discovery & Development
    • Commercializing Antibody Therapeutics
    • Antibodies to Watch
    • Antibody Validation
  • COVID-19
    • Guide to “Coronavirus in the Crosshairs”
    • Meeting Report: The Diagnostic Landscape for COVID-19
You are here: Home / The AIRR Community / On AIRR – An AIRR Community Podcast

On AIRR – An AIRR Community Podcast

The AIRR Community Diagnostics Working Group is excited to announce season 2 of the On AIRR podcast series!

The series aims to disseminate the goals and values of the Community, with a focus on their application to diagnostics and other clinical applications. We are committed to presenting conversations with a diverse group of experts, and gathering the attention of a broad audience, including students, and researchers from both industry and academia.

If you have questions for our next guest, suggestions for guests that you would like us to invite, or interesting topics to discuss, send us an email at onairr@airr-community.org.

If you share podcast-related content in social media, please use the hashtag #onairr.

Google Podcasts Spotify Apple Podcasts Amazon Music Podcasts

Upcoming Podcasts

PodcastDateDescription
S02 E05Aug 2023On AIRR 15: Germline antibodies
Guests: Corey Watson and William Lees
S02 E06Sep 2023On AIRR 16: Identification of neoantigens
Guest: Marion Arnaud

Podcast Episodes

PodcastDateDescription
S02 E04Jul 2023On AIRR 14: Data protection and data sharing
Guest: Alexander Bernier
Hosts: Dr. Ulrik Stervbo and Dr. Zhaoqing Ding

We discuss the risk of identifying individuals in a biological data set, how this is approached differently in different countries, and possible strategies to ensure data privacy. Our guest is Alexander Bernier BCL, JD, LLM, a lawyer with expertise in biological data sharing designs.
S02 E03Jun 2023On AIRR 13: Disease diagnostics using machine learning
Guests: Maxim Zaslavsky and Dr. Scott D. Boyd
Hosts: Dr. Ulrik Stervbo and Dr. Zhaoqing Ding

We discuss the preprint “Disease diagnostics using machine learning of immune receptors”, available at BioRxiv. The work is led by Maxim Zaslavsky with Scott Boyd the corresponding author. In the manuscript, the authors demonstrate how AIRR-seq and machine learning can be used in disease diagnostics
S02 E02May 2023On AIRR 12: T-cell receptor-mimetic antibodies and immunoinformatics
Guest: Prof. Charlotte Deane
Hosts: Dr. Ulrik Stervbo and Dr. Zhaoqing Ding

Prof. Charlotte Deane’s research merges statistics, immunoinformatics, protein structure and small molecule drug discovery. We discuss the relevance of including protein structure to study and design antibodies, and the availability of such data.
S02 E01Apr 2023On AIRR 11: Software as a Medical Device (SaMD)
Guest: Dr. Xenophon Papademetris
Hosts: Dr. Ulrik Stervbo and Dr. Zhaoqing Ding

Dr. Papademetris provides an overview of the typical regulatory process for software classified as a medical device. We draw from his experience in the medical image field to design a high level route map for an imaginary company bringing to the market software to diagnose minimal residual disease.
S01 E10Nov 2022On AIRR 10: Characterising B Cell Lymphomas or Profiting from a Focus on B Cells in Health and in Disease
Guest: Dr. Ralf Küppers
Hosts: Dr. Ulrik Stervbo and Dr. Zhaoqing Ding

Building upon Ralf’s background in B cell differentiation in health and pathogenesis of human B cell lymphomas, we discuss how micro-dissection and Sanger sequencing is still the method of choice when analysing Hodgkin lymphoma and the V-gene usage and mutations in CLL as prognostic indicators before talking about tracking pathogenic clones when surveying for relapse during clinical follow up.
S01 E09Oct 2022On AIRR 9: The ImmunoMind or wielding an AI for repertoire insights
Guest: Vadim Nazarov
Hosts: Dr. Ulrik Stervbo and Dr. Zhaoqing Ding

Vadim Nazarov is Co-Founder & CEO of the startup ImmunoMind. The company focuses on improving the design of adoptive T-cell therapies using multi-omics technologies. Vadim's career began at Dr. Dmitry Chudakov’s Laboratory of Adaptive Immunity, where he developed the now discontinued R-package TcR. The replacement package ‘immunarch’ is continuously developed by ImmunoMind.
S01 E08Sep 2022On AIRR 8: Engineering B cells or Giving the immune System an Optimal Starting Point
Guest: Dr. Adi Barzel
Hosts: Dr. Ulrik Stervbo and Dr. Zhaoqing Ding

Following Adi’s long standing interest in gene editing, we discuss the therapeutic potential based on Adi’s recent paper “In vivo engineered B cells secrete high titers of broadly neutralizing anti-HIV antibodies in mice” (Nat Biotechnol.; 2022; https://doi.org/10.1038/s41587-022-01328-9). We also briefly touch on a second paper on some of the problems with CRISPR-Cas9 gene editing (“Frequent aneuploidy in primary human T cells after CRISPR-Cas9 cleavage”; Nat Biotechnol.; 2022; https://doi.org/10.1038/s41587-022-01377-0)
S01 E07Aug 2022On AIRR 7: Quality Controls in AIRR-Seq Assays or Handling the Catastrophe
Guest: Dr. Encarnita Mariotti-Ferrandiz
Hosts: Dr. Ulrik Stervbo and Dr. Zhaoqing Ding

The discussion focuses on sample quality and how to assess this. We draw on two papers during the discussion: “Benchmarking of T cell receptor repertoire profiling methods reveals large systematic biases” (Nature Biotechnology; 2021; https://doi.org/10.1038/s41587-020-0656-3) and “Biological controls for standardisation and interpretation of adaptive immune receptor repertoire profiling” (eLife; 2021; https://doi.org/10.7554/eLife.66274).
S01 E06Jul 2022On AIRR 6: Data Sharing or Finding Glory, Fame and a Big Pile of Gold
Guests: Dr. Brian Corrie and Dr. Scott Christley
Hosts: Dr. Ulrik Stervbo and Dr. Zhaoqing Ding

In this episode we discuss possibilities for sharing AIRR-Seq data - repositories and metadata standards describing the samples and experimental process. We discuss AIRR Standards which includes MiAIRR Standard for dataset metadata and AIRR Data Commons, which is an API to query and download data from AIRR-Seq repositories. Complete and proper data annotation will bring fame and glory.
S01 E05May 2022On AIRR 5: Machine learning and AIRR or Looking for the needle in a needle stack
Guests: Dr. Lindsay Cowell and Dr. Victor Greiff
Hosts: Dr. Ulrik Stervbo and Dr. Zhaoqing Ding

Today we discuss machine learning with Dr. Lindsay Cowell and Dr. Victor Greiff. Machine learning is about pattern recognition and in AIRR-seq these patterns link repertoires to diseases and antigen binding. AIRR is nearly a perfect machine learning problem because the underlying patterns are unclear and complex - it is essentially looking for the needle in a needle stack.
S01 E04Apr 2022On AIRR 4: Understanding and engineering immune repertoires
Guest: Dr. Jacob Glanville
Hosts: Ulrik Stervbo and Zhaoqing Ding

Dr. Jacob Glanville is founder and CEO of Centivax and founder of Distributed Bio, acquired by Charles River in 2021. His work focuses on understanding and engineering the repertoires of T and B cells to improve the response to pathogens. In this episode we discuss how to analyze receptor specificity and use this to create therapeutic antibodies and optimize vaccine response.
S01 E03Mar 2022On AIRR 3: Outlining chronic lymphocytic leukemia
Guest: Dr. Anton Langerak
Hosts: Ulrik Stervbo and Zhaoqing Ding

Anton Langerak is Professor and head of Laboratory Medical Immunology at Erasmus MC in Rotterdam, Netherlands and chair of coordination of the EuroClonality-NGS working group. He has been working on chronic lymphocytic leukemia (CLL) for many years and in this episode we discuss the signatures of B cell receptors in CLL.
S01 E02Feb 2022On AIRR 2: Establishing an AIRR-Seq framework
Guest: Dr. Lindsay Cowell, PhD., Division of Biomedical Informatics, University of Texas Southwestern Medical Center at Dallas
Hosts: Ulrik Stervbo and Nidhi Gupta

In this episode, we discuss the interest of Lindsay Cowell from UT Southwestern in creating a framework to enable deeper understanding of AIRR-Seq in health and disease.
S01 E01Jan 2022On AIRR 1: MRD
Guest: Dr. Eline T. Luning Prak, MD, PhD. Professor of Pathology and Laboratory Medicine at the Hospital of the University of Pennsylvania
Hosts: Ulrik Stervbo and Nidhi Gupta

We talk a bit about the AIRR-Community but mostly we discuss diagnosis of B or T cell malignancies and minimal residual disease evaluation and tracking of B cell clones in autoimmunity.

AIRR Community News

Reconnect with the AIRR Data Commons: Your Gateway to Immunology Discoveries

September 19, 2023 By Edel Aron

The AIRR Community continues to spearhead innovation in immunology research with the ever-expanding AIRR Data Commons (ADC). For those unfamiliar, the ADC is a pioneering initiative that enables the sharing of standardized Adaptive Immune Receptor Repertoire (AIRR) data. This resource hosts a wealth of information about the diverse array of antibody/B-cell and T-cell receptors that […]

September Seminar Series

September 12, 2023 By Edel Aron

The September AIRR-C seminar is fast approaching! On September 28th at 7:00 PST/10:00 EST/16:00 CET, Pieter Meysman of the University of Antwerp will be discussing the applications of TCR-epitope prediction models and Felix Drost of Helmholtz Munich will be discussing the prediction of T cell receptor functionality against mutant epitopes. Register now! The seminar will […]

AIRR-C WG/SC Calls

All times are in ET (Americas/New York)

Click here for full calendar view

AIRR-C Seminar
10:00
Thu, September 28, 2023
Communications SC
13:00
Thu, September 28, 2023
Meetings SC
12:00
Mon, October 2, 2023
Common Repository WG
11:00
Thu, October 5, 2023
Call - GLDB (Asia-Pacific & Europe)
4:00
Wed, October 11, 2023

Recent AIRR Publications

Lees W.D. et al. AIRR Community curation and standardised representation for immunoglobulin and T cell receptor germline sets (Immunoinformatics, 2023)

See all publications

Archives

AIRR-C Glossary of Terms

Follow Us Online

  • Email
  • LinkedIn
  • Twitter
  • YouTube
  • Slack
  • Home
  • Privacy & Terms of Use
  • About
  • Directors and Officers
  • Advisors
  • Sponsors & Partners
  • Mission & Activities
  • Join the Society
  • Membership Levels
  • Members only
  • Login
  • Antibody therapeutics approved or in regulatory review in the EU or US
  • Meeting reports
  • Presentations
  • Contact

©2015 - scicomvisuals