Thursday October 26th at 11am ET/5pm CET
Versatility of Modular Antibodies: From Rapid Format Switch to Fast Screening of Libraries and Bispecifics
The SpyTag/SpyCatcher protein ligation technology is a versatile method to covalently link two proteins. Addition of the SpyTag protein ligation technology to antibodies creates a modular platform that offers a wide range of new opportunities. In this webinar Dr. Ylera will demonstrate the use of Spytagged antibodies in combination with prefabricated SpyCatcher modules for rapid site-specific labeling, as well as changing antibody valency, species and isotype. Furthermore, Dr. Ylera will present the use of SpyTag for antibody phage display selection (SpyDisplay) and for the generation of prototype bispecific antibodies. The work presented illustrates how these technologies work hand in hand for the generation of new therapeutic lead candidates.
Speaker: Francisco Ylera, PhD, Bio-Rad
Francisco Ylera is the head of the R&D team that generated the Pioneer Antibody Discovery Platform. He has been with Bio-Rad for over 18 years. Francisco has worked on customer antibody generation projects, and has been involved with designs selection, antibody characterization, and technical support, as well as method optimizations. Francisco holds a diploma in chemistry from RWTH Aachen University, Germany, and a Ph.D. in Biochemistry from the Free University Berlin, Germany. After his Ph.D., he did a postdoc at the Harvard Institute of Medicine, Boston, USA
Thursday November 9, 2023 11am ET/5pm CET
Strategies for Mitigating the Unpredictability of Fc-Mediated Functions in Antibody Development
Optimization of Fc function can lead to the development of safer and more efficacious therapeutic antibody products, but analyses of Fc function may be underexploited in the antibody design process. We introduce a high-throughput platform for antigen-specific testing of Fc effector activities, empowering enhanced hit-to-lead screening in early stages of antibody development for the treatment of cancer, autoimmunity, neurodegeneration, and infectious diseases.
Speaker: Lenny Moise, PhD, VP Research, SeromYx Systems
Dr. Lenny Moise, VP Research, oversees the scientific development of the SeromYx Systems Serology platform, driving clinical research and drug discovery in infectious disease, immuno-oncology, autoimmunity, and neurology. Previously, as Director of Vaccine Research at EpiVax, he harnessed immunoinformatics to design innovative vaccines leveraging T cell immunity for viral and bacterial infectious diseases and cancer. Over that time, he studied T cell responses to vaccines and developed immunoinformatic tools as a faculty member at the Institute for Immunology and Informatics (University of Rhode Island) and the Center for Vaccines and Immunology (University of Georgia). Lenny trained in structure-function analysis of snake toxin-ion channel interactions using structural, biochemical, and electrophysiological methods and holds a Bachelor of Science and a doctorate from Brown University.
Preview of other upcoming webinars:
- November 7, 2023, Quality Control Pipelines for T cell and B cell AIRR-seq.
- January 2024, Presentation by Huston Antibody Science Talent Award winner
- January 2024, Antibodies to Watch in 2024
Our selection of On Demand webinars can be viewed here.
Our YouTube channel includes selected webinars as well as recordings of our Symposia on topics such as:
- Computational Antibody Discovery: State of the Art
- Biopharmaceutical Informatics
- Harnessing Cytokines for Cancer Immunotherapy
- Emerging Immunotherapeutics for Ovarian Cancer Symposium
- Emerging Cancer Therapies Leveraging Gamma-Delta Effector T cells