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You are here: Home / The AIRR Community / AIRR Community Sub-committees / Inferred Allele Review Sub-committee (IARC)

Inferred Allele Review Sub-committee (IARC)

The Inferred Allele Review Sub-committee (IARC) was formed after the third AIRR-Community meeting in Rockville, MD in December 2017. The IARC is responsible for judging the validity of germline immunoglobulin and TCR genes inferred from AIRR-Seq data and advising IMGT and the IUIS/IMGT nomenclature committee of their findings. It also reviews inferred sequences and evidence in support of their existence and makes this data available to the AIRR community and other researchers through the OGRDB database. The work of the committee initially focused on human IGHV germline genes, but it is hoped that work will commence on the evaluation of other germline genes and species. Overall, the IARC aims to generate resources for and advocate for better practice in and understanding of IG and TR annotation and analysis in the community interested in studies of AIRR. 

Achievements

  • Began collating data for inferred human IGHV alleles from interested researchers, and established a formal submission process. 
  • Developed criteria for the review and acceptance of inferred IGHV alleles.
  • With William Lees and Adrian Shepherd of Birkbeck, University of London, co-developed OGRDB, a public resource for the submission, review and publication of previously unknown receptor germline sequences together with supporting evidence.
    • OGRDB has been integrated with VDJbase to simplify submission of VDJbase inferred alleles.
  •  In its first year of operation, 16 new IGHV alleles were approved by the IARC. All 16 sequences were subsequently given names by IUIS/IMGT Nomenclature Committee, and have been incorporated into the IMGT Reference Directory. 

Further details, including evidence in support of the inferences, can be found at the OGRDB website.

Goals for 2022-24

  • Affirmation of additional novel human IGHV, IGKV, IGLV, and TRV alleles and extension of partial genes
  • Identification of expressed AIRR alleles and publication of human IGV germline allele sets (in collaboration with other WGs)
  • Consolidation of a macaque IG germline set by providing expertise to other WGs/IARCs
  • Consolidation of the use of temporary labels in instances where formal gene assignment of alleles cannot be made with confidence (in collaboration with other WGs)
  • Further integration of genomic and transcriptomic data of genes and alleles of IG loci
  • Establishment of processes for allele submission and germline gene sets of other species to OGRDB (in collaboration with other WGs)
  • Submission of manuscript(s) on novel alleles and IARC processes
  • Publication of guidelines for the generation and growth of germline sets to establish formally recognized gene sets
  • Establishment of funding mechanisms moving forward
  • Consolidation of the human TCR IARC process
  • Development IARC sustainability.

Members

Co-leader: Mats Ohlin

Members: Andrew Collins, Martin Corcoran, James Heather, William Lees, Mats Ohlin (Co-lead), Ayelet Peres, Corey Watson and Gur Yaari. 

Products

  • 9 inferred immunoglobulin alleles submitted to and approved by IUIS
  • A published commentary on the use of short read sequencing for AIRR allele discovery
  • A submitted manuscript on Balb/c germline alleles identified by inference (co-authored with other WGs)
  • Germline gene sets for Balb/c and C57BL/6 mouse strains published on OGRDB

Related Resources

  • The OGRDB database documents the evaluation process of each submitted gene sequence, and provides access to evidence in support of affirmed inferences. 
  • The VDJbase database of genotypes and haplotypes is being developed in association with OGRDB, and provides evidence of the expression of germline genes in hundreds of individuals.
  • Discussion of some issues arising from activities of the Germline Database Working Group can be found at the B-T.CR Wiki.

Meeting Minutes

2023:

  • IARC Meeting 119 Minutes – 2023/04/03
  • IARC Meeting 118 Minutes – 2023/03/20
  • IARC Meeting 117 Minutes – 2023/03/06
  • IARC Meeting 116 Minutes – 2023/02/27
  • IARC Meeting 115 Minutes – 2023/02/09
  • IARC Meeting 114 Minutes – 2023/02/06
  • IARC Meeting 113 Minutes – 2023/01/23
  • IARC Meeting 112 Minutes – 2023/01/09

Archives:

  • 2022
  • 2021
  • 2020
  • 2019
  • 2018

Contact

iarc@airr-community.org

AIRR Community News

Reconnect with the AIRR Data Commons: Your Gateway to Immunology Discoveries

September 19, 2023 By Edel Aron

The AIRR Community continues to spearhead innovation in immunology research with the ever-expanding AIRR Data Commons (ADC). For those unfamiliar, the ADC is a pioneering initiative that enables the sharing of standardized Adaptive Immune Receptor Repertoire (AIRR) data. This resource hosts a wealth of information about the diverse array of antibody/B-cell and T-cell receptors that […]

September Seminar Series

September 12, 2023 By Edel Aron

The September AIRR-C seminar is fast approaching! On September 28th at 7:00 PST/10:00 EST/16:00 CET, Pieter Meysman of the University of Antwerp will be discussing the applications of TCR-epitope prediction models and Felix Drost of Helmholtz Munich will be discussing the prediction of T cell receptor functionality against mutant epitopes. Register now! The seminar will […]

AIRR-C WG/SC Calls

All times are in ET (Americas/New York)

Click here for full calendar view

AIRR-C Seminar
10:00
Thu, September 28, 2023
Communications SC
13:00
Thu, September 28, 2023
Meetings SC
12:00
Mon, October 2, 2023
Common Repository WG
11:00
Thu, October 5, 2023
Call - GLDB (Asia-Pacific & Europe)
4:00
Wed, October 11, 2023

Recent AIRR Publications

Lees W.D. et al. AIRR Community curation and standardised representation for immunoglobulin and T cell receptor germline sets (Immunoinformatics, 2023)

See all publications

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