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You are here: Home / Archives for mAbs

Results of the Imaging Calendar Competition announced!

August 2, 2023 by Silvia Crescioli

The Society’s Communication and Membership Committee is glad to announce that:

Federica Riccio (King’s College London) is the winner of our inaugural Imaging Calendar Competition! 

Congratulations!

 

Based on the results of our online poll, the winning image is “Surrounded” by Federica Riccio (King’s College London).

Title: Surrounded

Description: A human iPSC-derived cortical neuron (MAP2 – Cyan Hot) sits happily surrounded by astrocytes (GFAP – Red Hot)

Antibodies used: rat anti-GFAP (Invitrogen 13-0300) represented in Red Hot and rabbit anti-MAP2 (Antibodies-Online ABIN1742387) represented in Cyan Hot

Instrument used: confocal laser scanning microscope Leica TCS SP8 (Leica Microsystems)

The winner will receive:

  • broad exposure of their work,
  • a $400 cash prize,
  • and the option of a free registration to: 1) Schrödinger’s online course, Introduction to Computational Antibody Engineering; or 2) virtual or in-person Antibody Engineering & Therapeutics.

The winning image will be featured as the cover image for the 2024 volume of mAbs, and also as the cover image of the calendar. The calendar will be distributed at the 2023 Antibody Engineering & Therapeutics, in San Diego, in December.

 

We are also glad to reveal the scientists behind the other short-listed images. These images will be included as well in the calendar, one every month.

 

Virginia Metrangolo (University of Copenhagen), image title “Lightening up cancer cells with antibodies”

Jessica Anania (University of Southampton), image title “Cytoskeletal structures following FcR stimulation”

Gabriel Emilio Herrera-Oropeza (King’s College London), image title “Structure of an Unpatterned Cerebral Organoid”

Nathaniel Lam (GSK), image title “Vascularised tumour-on-chip model”

Josefa Chuh (Genentech), image title “Preclinical optimization of Ly6E-targeted ADCs for increased durability and efficacy of anti-tumor response”

Irene Rosa (University of Florence), image title “Double immunofluorescence staining of human tongue, with DAPI nuclear counterstain”

Peng Zhao (AstraZeneca), image title “Enhanced anti-angiogenetic effect of transferrin receptor-mediated delivery of VEGF-trap in a glioblastoma mouse model”

Sandra Lara (AstraZeneca), image title “Antibody dependent phagocytosis of 3D tumour spheroids opsonized with Rituximab anti-CD20”

Danielle Fails (Fortis Life Sciences), image title “Immune profiling of axillary lymph tissues”

Lorna Stewart (Fusion Antibodies), image title “Expression bottlenecks and antibody localisation in stably transfected CHO cells with a GFP marker”

Isabel Uwagboe (King’s College London), image title “”RAGE” against the machine”

 

We thank everyone who participated, and all our members and followers for taking the time to vote for the best image!

Watch for our next Imaging Calendar Competition in 2024!

Filed Under: Competition Tagged With: antibodies, competition, mAbs

2023 Research Competition winners!

July 27, 2023 by Silvia Crescioli

The Society’s Communication and Membership Committee is glad to announce the Research Competition winners! 

 

Our student winner is:

Mr. Matheus Oliveira De Souza (Ragon institute of MGH, MIT and Harvard, MIT, The University of Kansas)
Poster title: Enhanced antibody recognition against HIV resistant strains by directed evolution

 

Our post-doc winner is:

Dr. Nayara Braga Emidio (National Institutes of Health (NIH))
Poster title: Generation of neurokinin receptor ligands with specialized signalling properties via nanobody conjugation

 

The Antibody Society sponsors competitions each year to recognize and encourage the research activities of promising student/postdoctoral fellows. For the Research Competition, participants submitted a summary of their work on a topic related to antibody research. Winners (1 student and 1 post-doc) were selected based on originality, creativity, scientific merit, clarity of their research and its presentation.

Winners will receive:

  • broad exposure of their work,
  • a $400 cash prize,
  • and the option of a free registration to: 1) Schrödinger’s online course, Introduction to Computational Antibody Engineering; or 2) virtual Antibody Engineering & Therapeutics.

Congratulations to our winners and thanks to everyone who participated!

Watch out for our next Research Competition in 2024!

Information on past competitions and winners can be found here.

Filed Under: Competition Tagged With: antibodies, antibody discovery, antibody engineering, competition, mAbs

Imaging Competition voting is open!

July 5, 2023 by Silvia Crescioli

Congratulations to the 12 participants whose images have been short listed for the calendar!

This competition was designed to acknowledge and encourage the creativity of our members involved in imaging studies. We had a fantastic turn out and thank all entries for your efforts.

We have short-listed 12 images which will made into a calendar for distribution by The Antibody Society at the Antibody Engineering & Therapeutics meeting in December. Congratulations!

But we would like you, our members and followers, to decide the winner.

The winning image will be featured as the cover image for the 2024 volume of mAbs and the cover image of the calendar. Additionally the member who submitted the winning image will receive broad exposure of their work, a $400 cash prize, and the option of a free registration to:
1) Schrödinger’s online course, Introduction to Computational Antibody Engineering; or
2) virtual or in-person Antibody Engineering & Therapeutics.

Click here to vote – polls are open until the 31st of July

The winner will be announced on the 1st of August!

Please see the short listed images below.

Danielle Fails (Fortis Life Sciences): Immune profiling of axillary lymph tissues
Nathaniel Lam (GSK): Vascularised tumour-on-chip model

Sandra Lara (AstraZeneca): Antibody dependent phagocytosis of 3D tumour spheroids opsonized with Rituximab anti-CD20
Virginia Metrangolo (University of Copenhagen): Lightening up cancer cells with antibodies

Gabriel Emilio Herrera-Oropeza (King’s College London): Structure of an Unpatterned Cerebral Organoid
Isabel Uwagboe (King’s College London): “RAGE” against the machine

Lorna Stewart (Fusion Antibodies): Expression bottlenecks and antibody localisation in stably transfected CHO cells with a GFP marker.
Irene Rosa (University of Florence): Double immunofluorescence staining of human tongue, with DAPI nuclear counterstain

Surrounded: A human iPSC-derived cortical neuron (MAP2 – Cyan Hot) sits happily surrounded by astrocytes (GFAP – Red Hot).
Jessica Anania (University of Southampton): Cytoskeletal structures following FcR stimulation

Josefa Chuh (Genentech): Preclinical optimization of Ly6E-targeted ADCs for increased durability and efficacy of anti-tumor response
Peng Zhao (AstraZeneca): Enhanced anti-angiogenetic effect of transferrin receptor-mediated delivery of VEGF-trap in a glioblastoma mouse model

Filed Under: Competition, Uncategorized Tagged With: competition, imaging, mAbs

Call for papers: Attention Society members who are also authors!

July 3, 2023 by Janice Reichert

mAbs is the official journal of The Antibody Society. Each year, the journal’s publisher, Taylor & Francis, provides several article publishing charge (APC) waivers, with a value of up to $4000 USD / £3200 / €3840 / $5570 AUD each, that we may distribute to members. To be considered for an APC waiver, please submit pre-submission inquiries, which should include the authors, title, abstract, and general outline of the intended article, to membership@antibodysociety.org.

mAbs publishes high quality reports, reviews, and perspective articles covering a range of antibody R&D topics, including:

  • Design, engineering, and selection of antibody therapeutics, including antibody-drug conjugates, multispecific antibodies, and single-domain antibodies
  • Machine learning and artificial intelligence applications
  • Non-clinical studies of antibodies, such as mechanism of action studies, safety, and efficacy studies in animals
  • Manufacturing and formulation
  • Regulatory review and approval of antibody therapeutics

The deadline for submission of the APC waiver request is July 31, 2023.

The deadline for submission of the manuscript to the journal is January 31, 2024.

The selected recipients will be notified as soon as possible after the request submission deadline.

Please contact Janice Reichert (janice.reichert@antibodysociety.org) if you have questions.

Further information:

mAbs is a multidisciplinary, open access journal dedicated to the art and science of antibody research and development. The journal has a strong scientific and medical focus but serves a broad readership, including specialists in technology transfer, legal issues, investment, and the regulation of therapeutics.

The journal’s 2021 Impact Factor is 6.440 and, in total, articles are downloaded at a rate of over 1 million per year.

Members of The Antibody Society receive a 10% discount on article publication charges using their member code.

Filed Under: mAbs Tagged With: antibody discovery, antibody therapeutics, mAbs

Call for Papers: Collection on Bispecific and Multispecific Antibodies

October 29, 2022 by Janice Reichert

Antibodies and antibody-derived bispecifics are one of the most successful therapeutic classes due to their excellent target specificity and tunable drug-like properties. The ability to tailor antibody functions using modern engineering approaches has ushered in a new wave of bi- and multi-specific antibody therapeutics that unlock novel target classes, biology, and mechanisms of action for the treatment of human diseases. In this collection of reviews, we invite The Antibody Society members, mAbs readers, and the broader scientific community to contribute review articles focused on bispecific and multispecific antibody-based molecules. The reviews should narrate the current state of the art in bi- and multi-specific antibody therapeutics, challenges and opportunities, and speculate on new vistas for the field.

mAbs will waive publication charges for up to 8 of the best review articles selected from pre-submission inquiries, which should include the authors, title, abstract, and general outline of the intended review article.

The deadline for pre-submission enquiries is January 31, 2023.

We are particularly interested in reviews in the following topics:

•         Overview of bispecific and multispecific antibody platforms (includes but not limited to Fc engineering, heavy and light chain pairing methodologies, high throughput production methods, geometrical and valency considerations etc.).

•         Reviews on multispecific antibodies (beyond bispecifics i.e., more than two binding epitopes) and their applications.

•         Reviews on bispecifics and multispecific antibodies beyond oncology (i.e., neurology, infectious disease, ophthalmology, rare diseases etc.).

•         Reviews on various cell engagers (T cells, NK cells, macrophages etc.), overview of their design strategies, formats, applications and considerations for safety and tolerability in multiple disease areas.

•         Bispecific/Biparatopic and multispecific/multiparatopic targeting beyond antibodies (Antibody drug conjugates, antibody cytokine fusions, CAR-T/NK/M therapies, ProTACs etc) in various therapeutic areas.

•         Clinical development experience with bispecific and multispecific molecules with a focus on any or all of these areas: safety and tolerability, immunogenicity, biomarkers and/or bioanalytical assay development.

•         Reviews on tissue targeting via bispecific and multispecific antibodies, important considerations for safety, tolerability and preclinical and clinical development.

•         Focused review on developability of bispecific and multispecific molecules, CMC and manufacturing considerations. Bispecifics design and challenges in cell line development, upstream and downstream process development, analytical method development, product quality control strategy, process design and scale up, material demand and commercial manufacturing, regulatory guidance, etc.

Although these topics are especially of interest, we welcome well-written reviews in related areas as well. We intend to waive publication charges for up to 8 of the best review articles selected from pre-submission inquiries, which should consist of the title, abstract and general outline of the intended review article.

The deadline for submission of the completed review articles is August 15, 2023.

Please send pre-submission inquiries to Editor-in-Chief Dr. Janice Reichert (reichert.biotechconsulting@gmail.com), and Assistant Editors Drs. Nimish Gera (ngera@mythictx.com), Li Zhou (li.zhou@abbvie.com) and Jonathan Sockolosky (jonathan@curie.bio). Please feel free to contact us if you have any questions.

For examples of other mAbs Collections, please visit the journal website.

Filed Under: Antibody therapeutic, Bispecifics, mAbs, Multispecifics Tagged With: antibody therapeutics, bispecific, mAbs, multispecific

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