Post written by: Richard Begent, Ph.D., Emeritus Professor of Oncology, University College London James S. Huston Jr, Ph.D., antibody engineer and founding President of The Antibody Society, died in Boston on March 25, 2020. Jim Huston was a distinguished biophysicist and a pioneering antibody engineer; his creation of the single chain Fv (scFv) antibody was […]
Coronavirus in the crosshairs, Part 4: Antibody therapeutics
The Antibody Society’s series “Coronavirus in the crosshairs” examines the ongoing discovery and development of COVID-19 interventions for broad use, including small molecule and biologic drugs, and vaccines. Parts 1 and 2 examined re-purposed small molecule and biologic drugs and new vaccines, respectively, while Part 3 focused on COVID-19 convalescent plasma treatments in development. The […]
Molecular Biology Can Improve Antibody Drug Developability
Contributed by Nick Hutchinson, FUJIFILM Diosynth Biotechnologies The discovery and development of antibody therapeutics often adheres to a series of stages starting with target identification and progressing through lead generation, lead optimization, then testing in preclinical and clinical studies. Molecular biologists engineer antibodies during lead generation and optimization to improve a range of characteristics, including antibody […]
Everything you ever wanted to know about Antibody Validation
All webinars in our Antibody Validation series are now On Demand! Tool antibodies are the dominant affinity reagent for proteomics in cell biology, reflected by the over 4.5 million antibodies that are commercially available. Distinct from therapeutics or diagnostics, tool antibodies tend to be poorly characterized. This is echoed by many reports of catastrophic specificity, activity, identity and […]
The Importance of Antibody Reagent Validation
In case more examples are needed, two new reports describe problems associated with antibody reagents: I.E. Frohner et al., Antibodies recognizing the C terminus of PP2A catalytic subunit are unsuitable for evaluating PP2A activity and holoenzyme composition. Science Signaling 28 Jan 2020 S. Schuchner et al., The Myc tag monoclonal antibody 9E10 displays highly […]
