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Announcing AIRR Community Service Prize 2022 Nominations!

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The lifeblood of the AIRR Community is its members and others who join us, typically on a volunteer and uncompensated basis, to advance the AIRR Community mission to standardize, analyze and share AIRR-seq data. The AIRR Community Service Prize recognizes individuals who have contributed to the AIRR Community in significant and often under-appreciated ways.

 

 

Activities exemplifying the award criteria include:

  • Participating in one or more Working Groups or Sub-committees
  • Mentoring junior or trainee members
  • Assisting with organizing meetings, publications, or other communications 
  • Contributing to the AIRR Data Commons, e.g. substantial reviewing or data deposits
  • Other tasks that, in the opinion of AIRR Community leaders, constitute selfless acts of citizenship that reflect our core mission and values

The AIRR Community Service Prize(s) recipient(s) will be announced and awarded at the Gala Dinner during the AIRR Community Meeting VI in May 2022.

Nomination Criteria:

  • Must be a Member to nominate
  • Nominate more than one nominee
  • Don’t need to be a Member to receive the award
  • Nominations close April 10th, 2022

 Click here to log in to vote (AIRR Community Members only).

AIRR-C Meeting VI – Registration Is Live!

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The AIRR-C Meetings Sub-committee is excited to announce that registration is live!  Be sure to sign up soon to take advantage of the early bird discount!

AIRR Community Meeting VI “Exploring New Frontiers” will be held in La Jolla, CA from May 17-19, 2022.

REGISTER NOW

Exploring New Frontiers:  This meeting has two themed “Challenge Sessions” meant to:
(i) Initiate and implement a strategic plan for the AIRR Community that integrates the Working Groups’ activities toward the central goal of universally accepted AIRR-seq data standards;
(ii) Introduce the Community to multidimensional systems approaches for characterizing immune responses, and how AIRR-seq data can benefit such approaches.

 

Meetings and presentations will take place at the Hilton La Jolla Torrey Pines and a hotel room block has been arranged at a discounted rate. The meeting will provide opportunities for investigators and trainees to network, participate in AIRR Community Working Groups and Sub-committee meetings, enjoy world class presentations, poster sessions, and deep dive tutorials.

Sign up today!

Three newly certified AIRR-compliant software tools: ImmuneML, CompAIRR and Dandelion

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The AIRR Community is excited to announce that three tools have recently been certified as compliant with the AIRR-C v1.0 standard for AIRR-Seq software tools. These are ImmuneML – an ecosystem for machine learning analysis of adaptive immune receptor repertoires, CompAIRR – a tool for ultra-fast comparison of adaptive immune receptor repertoires by exact and approximate sequence matching, and Dandelion – a tool for analyzing single cell BCR/V(D)J 10x Genomics data. 

In an effort to enable rigorous and reproducible immune repertoire research at the largest scale possible, the AIRR-C Software Working Group has established a standard to validate software tools using the AIRR-C Standards and meeting a series of interoperability and quality criteria. Developers interested in certifying their tools should complete the checklist and submit it to the AIRR-C Software Working Group for evaluation and ratification by its members.

More details can be found at the website AIRR Software WG – Guidance for AIRR Software Tools.

All compliant tools will be issued a badge and listed on the website AIRR Software WG – List of Tools Certified as Compliant. The list includes SONAR, ImmuneDB, Immcantation, ImmuneML, CompAIRR and Dandelion.

Latest AIRR Community seminar available on YouTube

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If you are interested in understanding how to perform easy, fast and practical AIRR analysis, check out the latest video on the AIRR Community YouTube channel.

Learn about the “Exploration of single-cell and bulk immune repertoire data in R using Immunarch with application to immunotherapy” by speaker Vadim I. Nazarov, Co-Founder and CEO, ImmunoMind.

 

 

Join us for “Fundamentals of the Immune System”, Parts I & II

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Part I:  Organization of the immune system.
Thursday June 3, 2021, 11am – 1pm ET. 

Part II:  The immune system in action.
Tuesday June 15, 2021, 11am – 1pm ET.

In this 2-part workshop on the fundamentals of the immune system, Dr. Jamie Scott, Professor Emerita, Simon Fraser University, Canada, will first provide an overview of humoral and cellular immunity, and the basic structure of the immune system, including its cells, tissues and compartments, along with the “superhighway” of the immune system: the circulatory and lymphatic systems. In that context, innate and adaptive immune systems and their interaction, and the general timing and dynamics of immune responses will be presented.

The processes of lymphocyte development, including the various B- and T-cell subsets, positive and negative selection, and the genetic basis of B-cell and T-cell receptor diversification, will be presented to provide a clear idea of what adaptive-immune receptor repertoires (AIRRs) are, and in general terms, how they are currently assessed via high-throughput sequencing. Dr. Scott will then cover the signaling, activation, proliferation and differentiation of T-cell and B-cell clones in the context of lymphoid compartments where antigen is concentrated and presented to naïve and memory B and T cells. The role of co-stimulation in determining the type immune response generated will be emphasized.

In Part II, Dr. Scott will review the orchestration of systemic and mucosal immune responses, including the roles of tolerance and inflammation in these processes. Examples of immune responses to vaccines, chronic viral infection, and/or cancer, as well as autoimmunity, will be presented as variations on a common theme, reiterating the dynamics of the immune response. Some engineered immunotherapies, such as therapeutic antibodies, CAR-T cells and dendritic-cell vaccines, will be introduced as well.

The importance of AIRR-sequencing data to our understanding of immune responses will be emphasized throughout the latter half of this workshop.

Click here to register for Part I

Click here to register for Part II