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The AIRR-C Diagnostics Working Group published on the future of blood testing using AIRR technology

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The AIRR-C Diagnostics Working Group recently published a manuscript on using the immunome for blood testing in Frontiers in Immunology. In the manuscript, the AIRR-C discusses opportunities as well as the current state of immunome-based diagnostics and highlights some of the challenges involved. The authors conclude with a call to clinicians, researchers, and others to join efforts AIRR-C to realize the diagnostic potential of the immunome. In the paper, the researchers define immunome as “millions of V(D)J-rearranged antibody and T cell receptor genes collectively expressed by a person’s B cells (antibodies) and T cells”.

The Future of Blood Testing Is the Immunome. (Frontiers in Immunology, 2021).

Arnaout RA, Prak ETL, Schwab N, Rubelt F. Adaptive Immune Receptor Repertoire Community.

Interns looking for Integrated Immunology Projects

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The Friedrich Alexander University in Erlangen (Germany) is looking for PIs working in the AIRR-seq space to take on intern students. The internship should be a short scientific project spanning 8 weeks to 6 months. The application process starts in March and the internship is expected to start in October to December. You can read more information about it at  https://www.iimmune.nat.fau.de/ . 

Interested PIs should send an email to Simon Schäfer of the AIRR-C Communications Sub-committee (simon.schaefer@fau.de) for further details.

The Comms SC is interested in helping to facilitate matchmaking between PIs and students to engage in AIRR internship exchanges and this is the first step in that process.

Please add your name to the list today!

A newly certified AIRR-compliant software tool: The Immcantation Framework

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The AIRR Community is excited to announce that the Immcantation Framework has been certified as compliant with the AIRR-C v1.0 standard for AIRR-Seq software tools.

In an effort to enable rigorous and reproducible immune repertoire research at the largest scale possible, the AIRR-C Software Working Group has established a standard to validate software tools using the AIRR-C Standards and meeting a series of interoperability and quality criteria. Developers interested in certifying their tools should complete the checklist and submit it to the AIRR-C Software Working Group for evaluation and ratification by its members.

More details can be found at the website AIRR Software WG – Guidance for AIRR Software Tools.

All compliant tools will be issued a badge and listed on the website AIRR Software WG – List of Tools Certified as Compliant.

AIRR-dedicated Issue in the journal Current Opinion in Systems Biology 

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Ramit Mehr edited an issue on Systems immunology & host-pathogen interaction Current Opinion on Systems Biology to which many AIRR-C scientists have contributed. The issue encompasses eight original articles on the following topics: 

  1. Development of adaptive immune cells and receptor repertoires from infancy to adulthood, (2) Antigen discovery tools for adaptive immune receptor repertoire research
  2. The adaptive immune receptor repertoire community as a model for FAIR stewardship of big immunology data 
  3. Tools for adaptive immune receptor repertoire sequencing 
  4. Beyond bulk single-chain sequencing: Getting at the whole receptor 
  5. Disease susceptibility genes hidden in plain sight? 
  6. Mining adaptive immune receptor repertoires for biological and clinical information using machine learning 
  7. T cell repertoire sequencing as cancer’s liquid biopsy—can we decode what the immune system is coding? 

Read all articles here: https://www.sciencedirect.com/journal/current-opinion-in-systems-biology/vol/24/suppl/C.

Join the AIRR Community Slack Workspace!

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The AIRR Community is now using Slack as a communication tool to promote idea sharing and explore questions related to AIRR research.

Please email the AIRR-C Communications Sub-committee via comm@airrc.antibodysociety.org to request an invite and join the conversation. 

In your email, please specify the email address you’d like us to use for the invite.

Chat with you soon!

 

AIRR Community Slack Workspace Etiquette