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New episode of the On AIRR podcast is here!

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In this episode of On AIRR, we welcome Dr. Paul Thomas, of St. Jude Children’s Research Hospital.

Dr. Thomas shares his journey from immunoparasitology to pioneering TCR repertoire sequencing. The discussion covers the evolution from single-chain TCR sequencing to the development of high-throughput paired sequencing methods, culminating in the TIRTL-seq approach. Dr. Thomas explains the technical and computational challenges in TCR pairing, the innovations that made large-scale studies possible, and the importance of data quality and curation in the field. The episode highlights the impact of these advances on understanding immune responses and the future of AIRR-based diagnostics.

Listen now via your favorite podcast platform or here: http://onairr.airr-community.org. New episodes will be released monthly.

New episode of the On AIRR podcast is here!

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In this episode of On AIRR, we welcome Dr. Bjoern Peters, Professor at the La Jolla Institute for Immunology, to discuss the crucial role of high-quality data in AI-driven immunological predictions and diagnostics.

Dr. Peters shares his journey from theoretical physics to MHC-binding prediction, leading to his work on the Immune Epitope Database (IEDB) — the world’s largest resource for immune epitope data. He highlights how good data often outcompete algorithmic improvements and discusses the challenges of data standardization in immunology. The conversation also delves into epitope prediction, AIRR sequencing for diagnostics, and the need for rigorous model validation in clinical applications.

Listen now via your favorite podcast platform or here: http://onairr.airr-community.org. New episodes will be released monthly.

 

Season 3 of On AIRR is here!

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We’re thrilled to announce the launch of Season 3 of On AIRR, the official podcast of the AIRR Community. This season kicks off with an insightful discussion featuring Dr. Thierry Mora and Dr. Aleksandra Walczak —  co-leaders of the Statistical Biophysics Group at Laboratoire de physique de l’ENS (LPENS) in Paris, France.

Dr. Mora and Dr. Walczak, physicists by training, have been pioneers in applying biophysics, neuroscience, and information theory methods to the analysis of the adaptive immune system, particularly in the context of V(D)J recombination. In this episode, they discuss the challenges of quantifying diversity within the immune repertoire and provide an overview of the powerful software tools developed by their group.

Listen now via your favorite podcast platform or here: http://onairr.airr-community.org. New episodes will be released monthly.

On AIRR Podcast Episode 15 Now Available!

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In the latest episode of the On AIRR – An AIRR-C Podcast Series, Dr. Ulrik Stervbo and Dr. Zhaoqing Ding speak with Dr. Corey Watson and Dr. William Lees about the recent work by the Germline Database Working Group of the AIRR-Community. We discuss the challenges in creating a database to hold all relevant and potentially relevant germline information, especially in the light of increased discovery rate through technological advances and improved analysis pipelines. We also reflect on the complexity in handling personalized germline reference sets.

You can subscribe and listen in your favorite podcasting app or check out all of the On AIRR episodes here at http://onairr.airr-community.org or on the AIRR YT Channel. If you share podcast-related content in social media, please remember to use the hashtag #onairr!

On AIRR Podcast Episode 14 Now Available!

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In the latest episode of the On AIRR – An AIRR-C Podcast Series, Dr. Ulrik Stervbo and Dr. Zhaoqing Ding speak with Alexander Bernier BCL, JD, LLM, a lawyer with expertise in biological data sharing designs, about data protection and data sharing. We discuss the risk of identifying individuals in a biological data set, how this is approached differently in different countries, and possible strategies to ensure data privacy.

You can subscribe and listen in your favorite podcasting app or check out all of the On AIRR episodes here at http://onairr.airr-community.org or on the AIRR YT Channel. If you share podcast-related content in social media, please remember to use the hashtag #onairr!