Encarnita Mariotti-Ferrandiz is Associate Professor in Immunology from Sorbonne Université, working in the i3 lab directed by Prof. David Klatzmann, located at Pitié-Salpêtrière Hospital, in Paris. Since her PhD, she is involved in deciphering the Adaptive Immune Receptor Repertoire (AIRR) diversity in health and pathology with a major focus on T-cell biology. From sample to statistical modelling, she is interested in (i) refining T cell differentiation and selection knowledge in health and disease and (ii) identifying biomarkers of diseases. Her main field of research in immunology focus on the study of autoimmune in inflammatory diseases. T-cells and the T-cell receptor being a part of a whole in T-cell biology, she uses Systems Immunology approach to better characterize the immune system by coordinating the integration of multi-scale biological (deep cell phenotype, transcriptome, adaptome, microbiome) and clinical information (Transimmunom LabEx, iMAP RHU). She is involved in national projects (Transimmunom LabEx, iMAP RHU) as well as PI in international collaborative projects (AIR-MI and iReceptorPlus). In particular, through the iReceptorPlus project, she is involved in systems immunology data integration, including AIRR-data to efficiently and meaningfully link AIRR-data to the rest of the immune response related parameters. More details here and here. As Associate-Professor, she created and launched in 2019 the “Integrative and Systems Immunology” Master 2 curriculum at Sorbonne Université, with the aim to promote and train the future research generation to Systems Immunology as a whole, including AIRR.
With this expertise, I joined the AIRR Community in 2016 by attending the 2nd AIRR meeting. I then joined the AIRR Minimal Standards working group and contributed to the first version of MiAIRR standards. In 2017, after introducing my work and questioning regarding molecular biology method reproducibility and comparability, I volunteered together with Maggie Bostick to co-chair the Biological Resources working group of the AIRR-Community in 2017. The main goals being to assess the needs and development issues of AIRR-sequencing controls and standards. Together with the help of the WG members and the AIRR-Community, we launched a general survey revealing the complexity of the task behind generation of controls and standards. The results are being submitted for publication. Altogether, I’ll be happy to contribute to the dissemination of AIRR research progresses and help in the community organization by being part of the Executive Sub Commitee.