The Adaptive Immune Receptor Repertoire (AIRR) Community of The Antibody Society is a research-driven group that is organizing and coordinating stakeholders in the use of next-generation sequencing (NGS) technologies to study antibody/B-cell and T-cell receptor repertoires. AIRR sequencing has enormous promise for understanding the dynamics of the immune repertoire in vaccinology, infectious disease, autoimmunity, and cancer biology, but also poses substantial challenges that are being addressed by the AIRR Community. Its meetings and workshops are designed to develop standards and recommendations for:
- Obtaining, analyzing, curating and comparing/sharing NGS AIRR datasets
- Using and validating tools for analyzing AIRR data
- Relating AIRR NGS datasets to other “big data” sets, such as microarray, flow cytometric, and MiSeq gene-expression data
- Legal and ethical issues involving the use and sharing of AIRR data sets derived from human sources
The 4th AIRR Community Meeting was held May 11-15, 2019 at the University of Genoa in Italy.
The theme of this meeting, “Bridging the Gaps”, addressed technological gaps between the amounts of accumulated data and our ability to process them, and the need for more involvement of stakeholder communities (industry, clinicians, patent communities) for uptake of the standards developed by the AIRR Community. Two outstanding Keynote speakers participated– Dr. Sai Reddy from ETH Zurich and Dr. Antonio Lanzavecchia from IRB Bellinzona. Panel discussions included representatives from other institutions and companies that work with AIRR-seq data. In addition, two “challenge” sessions addressed the above-mentioned gaps. Two pre-meeting workshops covered the basics of immunology, and of AIRR-seq data analysis for beginners. Poster sessions and tool and software demonstrations were also provided. More information and the meeting agenda can be found here.
The 3rd AIRR Community Meeting was held December 3-6, 2017 at NIH’s Fishers Lane facility. Please go to the 3rd AIRR Community Meeting page for the full meeting agenda, and a link to the recorded videos of the sessions.
The 2nd AIRR Community Meeting was held June 27-30, 2016 at the National Institutes of Health (NIH)’s Fishers Lane facility. Please go to the 2nd AIRR Community Meeting page for the full meeting agenda, and a link to videos of the six sessions.