Thursday June 6, 2024 8am PT, 11am ET
Advancing early-stage bispecific discovery programs towards clinical success, with GS Discovery® and bYlok® technology
In this webinar Dr. Jin Lu will show how Lonza’s novel GS Discovery® transient expression platform can boost transient titers by ~30-fold to enable rapid early material supply, and streamline the transition from discovery to stable production. Dr. Lu will also introduce bYlok® bispecific pairing technology – an innovative solution that drives correct heavy-light chain pairing rates in IgG-like bispecifics to >95%. This improves yields of the correct species and streamlines downstream processing, without affecting key performance attributes of the molecule. Dr. Lu will present the latest case studies of bYlok® engineered bispecifics and explore how bYlok® compares to other established pairing solutions.
Key points:
- GS Discovery® supports high titer transient expression to rapidly generate material for early studies
- bYlok® bispecific pairing technology drives correct HC-LC pairing in bispecifics to >95%
- This overcomes issues during downstream processing
- bYlok® and GS Discovery® are accessible via a license agreement
Speaker: Dr. Jin Lu, PhD, Senior Technical Support Manager, Licensing, Lonza
Dr. Jin Lu is a senior technical support manager for technology licensing at Lonza. She has over 13 years of experience in biotherapeutic protein characterization, and a PhD in chemical biology from The University of Warwick, UK.
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Our YouTube channel includes selected webinars as well as recordings of our Symposia on topics such as:
- Computational Antibody Discovery: State of the Art
- Biopharmaceutical Informatics
- Harnessing Cytokines for Cancer Immunotherapy
- Emerging Immunotherapeutics for Ovarian Cancer Symposium
- Emerging Cancer Therapies Leveraging Gamma-Delta Effector T cells