The Antibody Society

the official website of the antibody society

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Register today for the first session of the year of the AIRR-C Seminar Series

January 16, 2024 by Edel Aron

January 2024 Seminar Banner

The first AIRR-C Seminar Series session of 2024 is around the corner! On January 25th (4:00 PM – 5:30 PM CET), following the usual format of the series, an established and an early career scientist will discuss their AIRR-seq related research. Enkelejda Miho, of the University of Applied Sciences and Arts Northwestern Switzerland, will present “Integration of Clinical, Laboratory, and Multi-omics Data to Leverage Machine Learning for Diagnostics”. Next, Stefan Schattgen, of the St. Jude Children’s Research Hospital, will present “Spatiotemporal development of the human T follicular helper cell response to Influenza vaccination”.

Register now! Visit the AIRR Community Seminar Series website to learn more about this monthly series and access the recordings of past sessions.

Filed Under: AIRR Community Tagged With: Adaptive Immune Receptor Repertoire Community, Seminar

AIRR Community Meeting VII Call for Abstracts

January 12, 2024 by Edel Aron

AIRR Community Meeting VII Banner

The time has come to submit abstracts for the upcoming AIRR-C meeting!

Software Demonstrations and Tutorials

We will have hands-on, one hour “deep dive” tutorials as well as short 10 minute “lightning” demonstrations of innovative software and tools. Don’t miss this opportunity to share your software and tools with the community. Submit your demo or tutorial abstract proposal today! The deadline for software demo and tutorial abstracts is January 18th, 2024.

Posters and Short Contributed Talks

Our fun and informative poster sessions are back! Submit an abstract to be considered for one of the poster sessions. 6 exceptional posters will be invited to give short contributed talks during the plenary sessions. The deadline for posters and short talk abstracts is February 15th, 2024.

Registration and travel award applications will launch in February 2024.

Filed Under: AIRR Community Tagged With: Adaptive Immune Receptor Repertoire Community, Meetings

“Antibodies to Watch in 2024” is now online!

January 5, 2024 by Janice Reichert

In this 15th installment of the annual ‘Antibodies to Watch’ article series, we review commercially sponsored monoclonal antibody therapeutics currently in late-stage clinical development, regulatory review, and those granted a first approval in any country in 2023. We also discuss clinical phase transition and overall approval success rates for antibody therapeutics, which are crucial to the biopharmaceutical industry because these rates inform decisions about resource allocation. Our analyses indicate that these molecules have approval success rates in the range of 14–32%, with higher rates associated with antibodies developed for non-cancer indications. Overall, our data suggest that antibody therapeutic development efforts by the biopharmaceutical industry are robust and increasingly successful.

Download or read the full paper here.

The complete abstract is here: The ‘Antibodies to Watch’ article series provides an annual summary of commercially sponsored monoclonal antibody therapeutics currently in late-stage clinical development, regulatory review, and those recently granted a first approval in any country. In this installment, we discuss key details for 16 antibody therapeutics granted a first approval in 2023, as of November 17 (lecanemab (Leqembi), rozanolixizumab (RYSTIGGO), pozelimab (VEOPOZ), mirikizumab (Omvoh), talquetamab (Talvey), elranatamab (Elrexfio), epcoritamab (EPKINLY), glofitamab (COLUMVI), retifanlimab (Zynyz), concizumab (Alhemo), lebrikizumab (EBGLYSS), tafolecimab (SINTBILO), narlumosbart (Jinlitai), zuberitamab (Enrexib), adebrelimab (Arelili), and divozilimab (Ivlizi)). We briefly review 26 product candidates for which marketing applications are under consideration in at least one country or region, and 23 investigational antibody therapeutics that are forecast to enter regulatory review by the end of 2024 based on company disclosures. These nearly 50 product candidates include numerous innovative bispecific antibodies, such as odronextamab, ivonescimab, linvoseltamab, zenocutuzumab, and erfonrilimab, and antibody–drug conjugates, such as trastuzumab botidotin, patritumab deruxtecan, datopotamab deruxtecan, and MRG002, as well as a mixture of two immunocytokines (bifikafusp alfa and onfekafusp alfa). We also discuss clinical phase transition and overall approval success rates for antibody therapeutics, which are crucial to the biopharmaceutical industry because these rates inform decisions about resource allocation. Our analyses indicate that these molecules have approval success rates in the range of 14–32%, with higher rates associated with antibodies developed for non-cancer indications. Overall, our data suggest that antibody therapeutic development efforts by the biopharmaceutical industry are robust and increasingly successful.

Filed Under: Antibody therapeutics pipeline, Approvals, European Medicines Agency, Food and Drug Administration Tagged With: Antibodies to watch, Antibody drug conjugates, antibody therapeutics, approved antibodies, bispecific, cancer, European Medicines Agency, Food and Drug Administration

Visit us at Antibody Engineering & Therapeutics, Booth #113!

December 8, 2023 by Janice Reichert

The Antibody Society

Antibody Engineering & Therapeutics commences on Thursday, December 14, 2023! Visit us at Booth #113 for a free T shirt and networking.

And don’t miss the keynote address by Dr. Heather Bax, the 2023 Huston Award recipient.

See you there!

Filed Under: Antibody Engineering & Therapeutics, Uncategorized Tagged With: antibody engineering, antibody therapeutics, Huston Award

The Nov 7th AIRR-C webinar is now available online

December 3, 2023 by Edel Aron

The last AIRR-C webinar “Quality Control Pipelines for T cell and B cell AIRR-seq”, by Dr. Encarnita Mariotti-Ferrandiz (Sorbonne Universite) and Dr. Nina Luning Prak (University of Pennsylvania) is now available online. 

Visit the AIRR Community Webinar Series website to learn more about this series and access the recordings of past sessions.

Filed Under: AIRR Community Tagged With: Adaptive Immune Receptor Repertoire Community, Webinar

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AIRR Community

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The Adaptive Immune Receptor Repertoire Community is a research-driven group organizing around the use of high-throughput sequencing technologies to study antibody/B-cell and T-cell receptor repertoires.

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