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You are here: Home / Archives for The Antibody Society

Antibodies to watch and more

June 27, 2019 by The Antibody Society

The Antibody Society’s presentation, “Antibodies to watch and more: Early and late-stage clinical development trends” was given on June 26, 2019, as part of KNect365’s Digital Week.

In this presentation, Dr. Janice Reichert, Executive Director of the Society, provided an update to the Antibodies to Watch in 2019 paper, which was published in mAbs in February. She gave a brief summary of antibody therapeutics approved January to June this year in either the US or EU, and antibodies in regulatory review and those that might enter regulatory review soon. Dr. Reichert also discussed trends for nearly 160 antibodies that entered clinical study from January 2018 to mid-June 2019, including use of different antibody formats and mechanisms of action, and she provided specifics regarding the popular and less trendy targets.

Click here to download the presentation and learn which antibodies are the ones to watch in 2019 and 2020!

Like this post but not a member? Please join!

The Antibody Society maintains a comprehensive table of approved mAb therapeutics and those in regulatory review in the EU or US. Located in the ‘Web Resources’ section of our website, the list is updated regularly and can be downloaded in Excel format.

Filed Under: Antibody therapeutic, Antibody therapeutics pipeline, Approvals Tagged With: antibody therapeutics, European Medicines Agency, Food and Drug Administration, pipeline

Winners of the Antibody Engineering & Therapeutics Student/Postdoc Poster Competition

November 18, 2018 by The Antibody Society

Congratulations to our winners!

To recognize the research activities of promising student and postdoctoral attendees of Antibody Engineering & Therapeutics, The Antibody Society sponsors a competition for our student/postdoc members who submit posters for display at the meeting. Our judges select the best work based on originality, relevance and perceived impact on the field of antibody R&D.

This year, our judges selected 3 student/postdocs winners who receive: 1) a complimentary registration to attend the conference and pre-conference sessions; 2) an opportunity to give a short oral presentation of their work in one of the conference sessions; and 3) support for travel expenses.

The winners of the contest are:

Madeleine Jennewein (Ph.D. candidate, Harvard University). Poster title: Trans-placental antibody transfer selects for highly functional antibodies

Junpeng Qi (Postdoctoral Associate, The Scripps Research Institute. Poster title: Potent and selective antitumor activity of a T cell-engaging bispecific antibody targeting a membrane-proximal epitope of ROR1

Pietro Sormanni (Borysiewicz Biomedical Sciences Fellow (postdoctoral), University of Cambridge). Poster title: Third generation antibody discovery: In silico rational design

Antibody Engineering & Therapeutics, the annual meeting of The Antibody Society, is managed by KNect365. The meeting will be held December 10-13, 2018 in San Diego, CA. Society members receive a 15% discount on the registration fee. Contact us at membership@antibodysociety.org for the code.

Like this post but not a member? Please join!

Filed Under: Meetings, The Antibody Society, Uncategorized Tagged With: antibody therapeutics

Congratulations to George P. Smith, Nobel Laureate, Chemistry 2018, for the Invention of Phage Display

October 18, 2018 by The Antibody Society

The Antibody Society congratulates Prof. George P. Smith, who will receive a 2018 Nobel Prize in Chemistry this December for his invention of phage display, and pioneering work on phage-library technology.

Read the 3 papers that started the field:

-Invention of phage display (Smith GP. Filamentous fusion phage: novel expression vectors that display cloned antigens on the virion surface. Science 1985)

– Improving phage display and affinity selection (Parmley SF, Smith GP. Antibody-selectable filamentous fd phage vectors: affinity purification of target genes. Gene 1988)

– Proof of concept for phage-displayed peptide libraries (Scott JK, Smith GP. Searching for peptide ligands with an epitope library. Science 1990)

As a postdoc with Prof. Smith, The Antibody Society Board Member Dr. Jamie K. Scott helped produce the proof of concept for phage-displayed peptide libraries.

Filed Under: Antibody discovery, phage display Tagged With: antibody discovery, phage display

Most read from mAbs

July 11, 2018 by The Antibody Society

The Antibody Society is pleased and proud to be affiliated with mAbs, a multi-disciplinary journal dedicated to advancing the art and science of antibody research and development. We hope you enjoy these brief summaries based on the abstracts of the most read papers published in recent issues. All the articles are open access; PDFs can be downloaded by following the links below.

Issue 10.5 (July 2018)

The “less-is-more” in therapeutic antibodies: Afucosylated anti-cancer antibodies with enhanced antibody-dependent cellular cytotoxicity. In this new review, Pereira et al. discuss the relevance of antibody core fucosylation to antibody-dependent cell-mediated cytotoxicity, and different strategies to produce afucosylated antibodies, and provide an update of afucosylated antibody drugs currently undergoing clinical trials, as well as those that have been approved.

A long non-coding SINEUP RNA boosts semi-stable production of fully human monoclonal antibodies in HEK293E cells. Sasso et al. report the results of their study of SINEUP technology applied to semi-stable production of monoclonal antibodies in HEK293E cells. SINEUP RNAs are long non-coding transcripts, possessing the ability to enhance translation of selected mRNAs. The authors propose SINEUP technology as a valuable tool to enhance semi-stable antibody production in human cell lines.

Prediction of non-linear pharmacokinetics in humans of an antibody-drug conjugate (ADC) when evaluation of higher doses in animals is limited by tolerability: Case study with an anti-CD33 ADC. Figueroa et al. present a practical approach that uses limited pharmacokinetic (PK) and receptor occupancy (RO) data of the corresponding unconjugated antibody to predict ADC PK when conjugation does not alter the non-specific clearance or the antibody-target interaction. Their findings showed that, for a cytotoxic ADC with non-linear PK and limited preclinical PK data, incorporating RO in the PK model and using data from the corresponding unconjugated antibody at higher doses allowed the identification of parameters to characterize monkey PK and enabled human PK predictions.

Linear pharmacokinetic parameters for monoclonal antibodies are similar within a species and across different pharmacological targets: A comparison between human, cynomolgus monkey and hFcRn Tg32 transgenic mouse using a population-modeling approach. In this report, Betts et al. used population-pharmacokinetic (popPK) modeling to determine a single set of ‘typical’ popPK parameters describing the linear PK of mAbs in human, cynomolgus monkey and transgenic mice expressing the human neonatal Fc receptor (hFcRn Tg32), using a rich dataset of 27 mAbs. Translational strategies were investigated for prediction of human linear PK of mAbs, including use of typical human popPK parameters and allometric exponents from cynomolgus monkey and Tg32 mouse. Each method gave good prediction of human PK with parameters predicted within 2-fold. These strategies offer alternative options to the use of cynomolgus monkeys for human PK predictions of linear mAbs, based on in silico methods (typical human popPK parameters) or using a rodent species (Tg32 mouse), and call into question the value of completing extensive in vivo preclinical PK to inform linear mAb PK.

Issue 10.4 (May/June 2018)

When monoclonal antibodies are not monospecific: Hybridomas frequently express additional functional variable regions. Bradbury et al. discuss results of their study, which analyzed 185 random hybridomas, in a large multicenter dataset, to determine the genetic diversity in antibody heavy chain and light chain genes found within individual hybridomas. Of the hybridomas evaluated, 126 (68.1%) contained no additional productive chains, while the remaining 59 (31.9%) contained one or more additional productive heavy or light chains. The expression of additional chains degraded properties of the antibodies, including specificity, binding signal and/or signal-to-noise ratio, as determined by enzyme-linked immunosorbent assay and immunohistochemistry. Their findings, reflecting the current state of hybridomas used in research, reiterate the importance of using sequence-defined recombinant antibodies for research or diagnostic use.

Evaluation of analytical similarity between trastuzumab biosimilar CT-P6 and reference product using statistical analyses. In this report, Lee et al. evaluated analytical similarity of CT-P6, a biosimilar product of trastuzumab, with the reference products (EU-Herceptin® or US-Herceptin®) following risk-based statistical approaches recommended in a recent US Food and Drug Administration guideline for the risk-based statistical approaches recommended by the US Food and Drug Administration. Various quality attributes of trastuzumab were first ranked based on the clinical impact of each attribute and subsequently adjusted to one of three tiers (Tier 1, Tier 2 and Tier 3) considering the characteristics of the assay, the level of attribute present and the feasibility of statistical analysis. Analytical similarity assessment analyzed by the three tiers clearly demonstrated that CT-P6 exhibits highly similar structural and physicochemical properties, as well as functional activities, compared with the reference products.

Analytical and functional similarity of Amgen biosimilar ABP 215 to bevacizumab. Seo et al. report the results of their analytical similarity assessment, which was designed to assess the structural and functional similarity of ABP 215 and bevacizumab sourced from both the United States (US) and the European Union (EU). Similarity assessment was also made between the US- and EU-sourced bevacizumab to assess the similarity between the two products. More than 20 batches of bevacizumab (US) and bevacizumab (EU), and 13 batches of ABP 215 representing unique drug substance lots were assessed for similarity. The large dataset allows meaningful comparisons and garners confidence in the overall conclusion for the analytical similarity assessment of ABP 215 to both US- and EU-sourced bevacizumab. The structural and purity attributes, and biological properties of ABP 215 are demonstrated to be highly similar to those of bevacizumab.

 

Like this post but not a member? We encourage you to join the Society to take advantage of the substantial benefits of membership, including discounts on fees for selected KNect365, CHI, and Hanson Wade meetings, discounted subscriptions to Society-affiliated journals PEDS and mAbs (special subscription rate of US $84 online only access for Antibody Society members)  and access to information in the Members Only section of the website. In particular, we encourage members to take advantage of the discount on registration for Antibody Engineering & Therapeutics, which is the annual meeting of The Antibody Society traditionally held in San Diego in December. Membership is free for students, post-docs and employees of our corporate sponsors!

Filed Under: Ab news, New articles Tagged With: antibody therapeutics, biosimilar, mAbs

Sanne van de Bovenkamp wins The Antibody Society’s first Award for Excellence!

June 29, 2018 by The Antibody Society

Stimulating scientific exchange and education represent important aims of The Antibody Society. The Society therefore supports conferences in the antibody field through financial means and by providing scientific programming advice. The recognition of young and upcoming scientists with an Award for Excellence for best abstracts and presentations is a new Society initiative.

The Society’s first Award for Excellence was presented at the Waddensymposium, Antibodies: Central Players in Therapy and Disease, which was held June 25-26, 2018 in the remote town of Ouddorp in The Netherlands. An independent jury consisting of Prof. Stephen Beers (University of Southampton) and Dr. René Pfeiffle (University of Erlangen) selected Sanne van de Bovenkamp as the overall winner. The jury indicated that they were not only highly impressed by the quality of Sanne’s presentation but also by her demonstrated ability to engage in an insightful scientific discussion.

In her presentation, Sanne described her recent work on the impact of Fab-domain glycosylation in the adaptive antibody response. Her studies demonstrate that Fab-domain glycosylation is subject to clonal selection and impacts on antibody affinity. Sanne performed her graduate work at Sanquin Research with Dr. Theo Rispens.  She is currently a postdoc at the department of Immunohematology and Blood Transfusion at the Leiden University Medical Center in Leiden with Prof. Leendert Trouw. She is pictured here with Society Board of Director’s member Dr. Paul W.H.I. Parren and Prof. Beers.

Filed Under: Award for Excellence, Meetings, The Antibody Society Tagged With: antibody therapeutics, Award for Excellence

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