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AIRR-dedicated Issue in the journal Current Opinion in Systems Biology 

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Ramit Mehr edited an issue on Systems immunology & host-pathogen interaction Current Opinion on Systems Biology to which many AIRR-C scientists have contributed. The issue encompasses eight original articles on the following topics: 

  1. Development of adaptive immune cells and receptor repertoires from infancy to adulthood, (2) Antigen discovery tools for adaptive immune receptor repertoire research
  2. The adaptive immune receptor repertoire community as a model for FAIR stewardship of big immunology data 
  3. Tools for adaptive immune receptor repertoire sequencing 
  4. Beyond bulk single-chain sequencing: Getting at the whole receptor 
  5. Disease susceptibility genes hidden in plain sight? 
  6. Mining adaptive immune receptor repertoires for biological and clinical information using machine learning 
  7. T cell repertoire sequencing as cancer’s liquid biopsy—can we decode what the immune system is coding? 

Read all articles here: https://www.sciencedirect.com/journal/current-opinion-in-systems-biology/vol/24/suppl/C.

AIRR Community and PrecisionFDA COVID-19 Precision Immunology App-a-thon

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The AIRR Community is helping to lead the PrecisionFDA COVID-19 Precision Immunology App-a-thon.  

This is part of the “precisionFDA Challenges” program, which is designed to engage and improve software that analyzes NGS (next generation sequencing data) through community challenges. There were 68 bioinformaticians pre-registered for the Precision Immunology Challenge, and more are expected to join as the app-a-thon continues.  These “citizen scientists” will form teams to design software that will make AIRR-seq data more available and accessible for immunologists to realize the promise of immunological big data for improved diagnostics and therapeutics in immunotherapy.

The Precision Immunology Challenge uses AIRR-seq repertoire data from COVID-19 patients downloaded from the AIRR Data Commons (VDJServer and iReceptor Public Archive) through the iReceptor Gateway. These data sets have been carefully chosen to include data on patient demography and clinical outcome in order to illuminate the relationship between personalized adaptive immunity molecular data and COVID-19 disease variables.

The AIRR Community Diagnostics Working Group published a blog post as part of this effort, explaining the possible uses of AIRR-seq data in the clinic in the near future.

The app-a-thon runs through February 2021 at which time the apps will be judged for usability, impact and innovation.

 

Announcing the new AIRR Community Executive Sub-committee!

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As part of the recent AIRR-C Meeting V the Executive Sub-committee election results were announced. Thank you to all nominees for their interest and for letting their names stand and to the many community members that took the time to vote.
We would like to thank Nina Luning Prak for her excellent and tireless work as Chair these past 18 months.  We would also like to recognize Steve Kleinstein for his many years on Exec and for his long standing commitment to the AIRR Community.
Please welcome the new Executive:
Lindsay Cowell, University Texas Southwestern, USA – Chair
Nina Luning Prak, University of Pennsylvania, USA – Past Chair
Victor Greiff, University of Oslo, Norway – Chair-elect
Felix Breden, Simon Fraser University, Canada – Elected Member
Christian Busse – DKFZ, Germany – Elected Member
Encarnita Mariotti-Ferrandiz, – Sorbonne Universite, France – Elected Member

AIRR Community 2021 Plans Ratification Vote!

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AIRR Community Working Groups and Sub-committees presented their 2020 reports and 2021 plans today at AIRR Meeting V: “Zooming in to the AIRR Community.” According to AIRR-C governance these plans must be ratified by the Community.
The reports and plans are available through the AIRR Meeting V meeting platform. Each report is attached to the agenda item that it corresponds to. If you are not registered for Meeting V but an eligible voting member you can access the report slides by logging in to the AIRR Community Resources section of the AIRR website.
Time is short – Voting closes at midnight PDT on December 9th!

Voting is now closed.

Vote by December 4th! AIRR-C Executive SC 2020 Election

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AIRR-C Executive SC 2020 Election – It’s Time to Vote!!

With each major meeting interval of the AIRR Community, elections are held for leadership positions within the AIRR-C Executive Sub-committee. This year, per our governance, we have sought nominations for Executive SC Chair-Elect and up to three members of the Executive SC.  We are pleased to announce that we have a strong set of candidates and we are grateful to all the nominees for letting their name stand.

How to Vote:

Voting is now complete. Results are available here.

Election Timeline:

Voting opens: November 24, 2020
Polls close: December 4, 2020
Voting results announced: December 10, 2020 (last day of the AIRR-C meeting)

Thank you for all of the time you give to the AIRR Community and for participating in this election!