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You are here: Home / Archives for AIRR Community

AIRR Community and Tsinghua University discuss Chinese research using AIRR-seq data to study adaptive immune response in COVID-19 patients

May 13, 2021 by Pam Borghardt

A meeting focusing on Chinese researchers’ use of AIRR-seq data to study the adaptive immune response – especially in COVID-19 patients – was held recently by the AIRR Community and Tsinghua University.

The purpose of this co-organized meeting was to expose AIRR-seq researchers in China to the philosophy and tools developed by the AIRR Community and help integrate researchers from all over the world through the AIRR Community.

Although collaboration and sharing data internationally is complicated and difficult, this successful meeting was an important step in forming the relationships necessary for overcoming many of these challenges.

Tsinghua University is a major research university in Beijing and a member of the C9 League of Chinese universities. Since its establishment exactly 110 years ago, it has produced many notable leaders in science, engineering, politics, business, academia, and culture. The university is ranked as the 15th best university in the world in the QS World University Rankings and No.1 in Asia by the Asia University Rankings and the U.S. News and World Report.

The meeting followed a hybrid format, combining online lectures by AIRR Community members in the US and Europe in conjunction with an in-person meeting in Shenzhen, China that was organized by Professor Xiao Liu of Tsinghua University’s Shenzhen campus.

The in-person, all-day meeting was held on December 6, 2020 in Shenzhen, which corresponded to Saturday evening December 5 in North America.

The full meeting agenda can be found on the meeting web page and the meeting recording has been posted on the AIRR-C YouTube Channel.

 

Filed Under: AIRR Community, Coronavirus, COVID-19, Uncategorized Tagged With: Adaptive Immune Receptor Repertoire Community, COVID-19, Meetings, SARS-CoV-2

Prof. Victor Greiff’s webinar is now available On Demand!

April 5, 2021 by Janice Reichert

In case you missed Prof. Victor Greiff’s very popular webcast on best practices relating to the conception, analysis and performance of adaptive immune receptor repertoire studies, the On Demand version is now online!

High-throughput sequencing has enabled the capture of adaptive immune receptor repertoire (AIRR) data at unprecedented depth and precision. This webinar gives an in-depth walk-through of best practices to conceive, analyze and perform AIRR studies for answering fundamental immunological questions as well as discovering novel immunodiagnostic biomarkers and design (therapeutic) immune receptors. Specifically, Dr. Greiff addresses current approaches to perform AIRR-compliant AIRR data processing encompassing bulk and single-cell approaches and experimental and bioinformatics quality control. Furthermore, he summarizes the computational methods that have been recently developed to deconstruct the high-dimensional complexity of immune receptor repertoires, e.g., 1) diversity-, 2) phylogenetic-, 3) networks- and 4) machine learning-based methods that have been applied to dissect and understand the diversity, architecture, evolution and antigen specificity of immune repertoires. Finally, Dr. Greiff discusses experimental and computational methods in light of their underlying assumptions, limitations and pitfalls and highlight promising avenues of future research in basic and applied AIRR systems immunology.

Click here to access the On Demand webinar!

Filed Under: AIRR Community Tagged With: Adaptive Immune Receptor Repertoire Community

The AIRR Community has started a Webinar Series

March 30, 2021 by Pam Borghardt

The AIRR Community is pleased to announce that it has started a Webinar Series. Webinars will include current AIRR-related topics as well as tutorials. The inaugural Webinar is on “Steps in data processing and analysis of adaptive immune receptor repertoires: best practices, pitfalls, and future directions” by Prof. Victor Greiff, University of Oslo (Norway), April 6, 2021. The Seminar is free, available on-demand and on the AIRR YouTube channel.

 

Filed Under: AIRR Community Tagged With: Adaptive Immune Receptor Repertoire Community, data processing

The AIRR-C Diagnostics Working Group published on the future of blood testing using AIRR technology

March 10, 2021 by Pam Borghardt

The AIRR-C Diagnostics Working Group recently published a manuscript on using the immunome for blood testing in Frontiers in Immunology. In the manuscript, the AIRR-C discusses opportunities as well as the current state of immunome-based diagnostics and highlights some of the challenges involved. The authors conclude with a call to clinicians, researchers, and others to join efforts AIRR-C to realize the diagnostic potential of the immunome. In the paper, the researchers define immunome as “millions of V(D)J-rearranged antibody and T cell receptor genes collectively expressed by a person’s B cells (antibodies) and T cells”.

The Future of Blood Testing Is the Immunome. (Frontiers in Immunology, 2021).

Arnaout RA, Prak ETL, Schwab N, Rubelt F. Adaptive Immune Receptor Repertoire Community.

Filed Under: AIRR Community Tagged With: Adaptive Immune Receptor Repertoire Community, diagnostics

Interns looking for Integrated Immunology Projects

March 6, 2021 by jpburckert

The Friedrich Alexander University in Erlangen (Germany) is looking for PIs working in the AIRR-seq space to take on intern students. The internship should be a short scientific project spanning 8 weeks to 6 months. The application process starts in March and the internship is expected to start in October to December. You can read more information about it at  https://www.iimmune.nat.fau.de/ . 

Interested PIs should send an email to Simon Schäfer of the AIRR-C Communications Sub-committee (simon.schaefer@fau.de) for further details.

The Comms SC is interested in helping to facilitate matchmaking between PIs and students to engage in AIRR internship exchanges and this is the first step in that process.

Please add your name to the list today!

Filed Under: AIRR Community, Systems Immunology Tagged With: Adaptive Immune Receptor Repertoire Community, AIRR-seq, Systems Immunology

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AIRR Community News

New episode of the On AIRR podcast is here!

June 26, 2025 By Lorissa Corrie

In this episode of On AIRR, we welcome Dr. Paul Thomas, of St. Jude Children’s Research Hospital. Dr. Thomas shares his journey from immunoparasitology to pioneering TCR repertoire sequencing. The discussion covers the evolution from single-chain TCR sequencing to the development of high-throughput paired sequencing methods, culminating in the TIRTL-seq approach. Dr. Thomas explains the […]

Zooming into the Community III — A Milestone Virtual Gathering!

June 3, 2025 By Lorissa Corrie

On May 21–22, 2025, the AIRR Community came together for our third “Zooming into the Community” virtual meeting, celebrating 10 years of collaborative science and innovation in immune receptor research. 📊 Attendance Highlights: Day 1: 106 registered / 68 attendees Day 2: 131 registered / 82 attendees This year’s mid-cycle event, themed “Specificity”, sparked critical […]

AIRR Community WG Calls

All times are in ET (Americas/New York)

Click here for full calendar view

Call - Standards WG
12:00
Thu, July 10, 2025
AIRR-C Executive Council Meeting
11:00
Thu, July 17, 2025
Call - Comms & Meetings SC
12:00
Fri, July 18, 2025
Call - ComRepo WG
11:00
Thu, August 7, 2025
Call - Standards WG
12:00
Thu, August 14, 2025

Recent AIRR Publications

Lees W.D. et al. AIRR Community curation and standardised representation for immunoglobulin and T cell receptor germline sets (Immunoinformatics, 2023)

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