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On AIRR Podcast Episode 8 Available Now

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In the latest episode of the On AIRR – An AIRR-C Podcast Series, Dr. Ulrik Stervbo and Dr. Zhaoqing Ding sit down with Dr. Adi Barzel, an associate professor of Biochemistry & Molecular Biology at Tel Aviv University and president of the Israeli Society of Gene and Cell Therapy. They discuss the therapeutic potential of engineered B cells as well as some of the problems with CRISPR-Cas9 gene editing.

You can listen to the episode (as well as past episodes) here or wherever you may find your podcasts. There are another three episodes scheduled for later this fall. If you share podcast-related content in social media, please remember to use the hashtag #onairr!

AIRR Community Standards v1.4 Now Available

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The AIRR Community is pleased to announce the release of v1.4 of the AIRR Standards, including v1.2 of the AIRR Data Commons API (ADC API) to query AIRR compliant data repositories. This release enables additional compatibility with single-cell and emerging technologies, supports extended data/metadata capture, and improves data standardization and integration. Major changes include updated quantification fields and conversion of several fields to ontology references to provide consistency across studies.

Several exciting experimental releases are included in this update: new Germline and Genotype schemas for documenting VDJ germline reference sequences and subject VDJ and MHC genotypes, extensions to the Cell schema for storing single-cell gene expression and receptor reactivity, and data aggregation schemas to facilitate more complex and reproducible analyses.

The ADC API specification included in this release contains new capabilities for querying AIRR v1.4 Schema objects including Clone, Cell, CellExpression, and Receptor objects.

Check out these key links:

Python Package

R Package

Release Notes

Github

Check out the On AIRR – An AIRR-C Podcast series!

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If you haven’t already done so check out the On AIRR – An AIRR-C Podcast series.

The series aims to disseminate the goals and values of the Community, with a focus on their application to diagnostics and other clinical applications. Organizers are committed to presenting conversations with a diverse group of experts, and gathering the attention of a broad audience, including students, and researchers from both industry and academia.

There are seven podcasts available so far through Google, Spotify, Apple and Amazon with another four scheduled this Fall.

If you share podcast-related content in social media, please remember to use the hashtag #onairr!

Welcome to our new AIRR Community Executive Sub-committee!

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We are excited to announce the new AIRR Community Executive Sub-committee recently elected at the AIRR Community Meeting. The AIRR-C Executive Sub-committee comprises a Chair (Victor Greiff), a Chair-Elect (Encarnita Mariotti-Ferrandiz), a Past Chair (Lindsay Cowell), and three elected Members of the AIRR Community (Christian Busse, Nina Luning Prak and Corey Watson). To learn more about the AIRR-C Exec SC members visit their webpages.

Join us on June 9th for our next webinar – Registration is open!

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In this webinar, Drs. Deane, Raybould and Boyles will share examples of how structure prediction enriches antibody sequence data and provide practical guidance for getting started using Oxford Protein Informatics Group (OPIG) tools to structurally featurise your antibody sequences. In particular, they will demonstrate the added value to tasks such as antibody functional clustering, repertoire disease-response diagnosis, and virtual screening.

Speaker bios are here.

Registration is open!