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New episode of the On AIRR podcast is here!

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In this episode of On AIRR, we welcome Dr. Paul Thomas, of St. Jude Children’s Research Hospital.

Dr. Thomas shares his journey from immunoparasitology to pioneering TCR repertoire sequencing. The discussion covers the evolution from single-chain TCR sequencing to the development of high-throughput paired sequencing methods, culminating in the TIRTL-seq approach. Dr. Thomas explains the technical and computational challenges in TCR pairing, the innovations that made large-scale studies possible, and the importance of data quality and curation in the field. The episode highlights the impact of these advances on understanding immune responses and the future of AIRR-based diagnostics.

Listen now via your favorite podcast platform or here: http://onairr.airr-community.org. New episodes will be released monthly.

Zooming into the Community III — A Milestone Virtual Gathering!

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On May 21–22, 2025, the AIRR Community came together for our third “Zooming into the Community” virtual meeting, celebrating 10 years of collaborative science and innovation in immune receptor research.

📊 Attendance Highlights:

  • Day 1: 106 registered / 68 attendees
  • Day 2: 131 registered / 82 attendees

This year’s mid-cycle event, themed “Specificity”, sparked critical discussion on defining, measuring, and curating immune receptor specificity. A big thanks to the organizers of the event, the joint Meetings & Communications Sub-Committee, who were building on the success of our past events (Special Event “Response to COVID-19” and Zooming II).

🧠 Event Highlights:

  • Presentations from AIRR Working Groups, Review-Committees, and Sub-Committees on key developments and future directions
  • A special General Assembly celebrating our 10-year anniversary
  • Outstanding invited speakers:
    • Antonio Lanzavecchia (INGM, Italy)
    • Victor Greiff (University of Oslo, Norway)
    • Maria Rodriguez Martinez (Yale University, USA)
    • David Klatzmann (Sorbonne Université, France)

🎥 Missed it? Sessions were recorded and will be available soon on the AIRR Community YouTube Channel.

📖 Want to read more? See the event page here.

Thanks to all who participated and contributed to this vibrant community event! Here’s to another decade of discovery. 💡

Register now for the June 26th AIRR Community Seminar Series

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Registration for the June 26th (4:00 PM – 5:30 PM CET) AIRR-C Seminar Series session is open. Following the usual format of the series, an established and an early career scientist will discuss their AIRR-seq related research.

Rohit Singh, Duke University, USA will present “Deciphering Structure-Function Convergence in B-Cell Receptor Repertoires with AbMAP.” Next, Joshua J.C. McGrath, Weill Cornell Medicine, USA will present “Mutability and hypermutation antagonize immunoglobulin codon optimality.”

REGISTER NOW!

Visit the AIRR Community Seminar Series website to learn more about this monthly series and access the recordings of past sessions.

Zooming into the Community III Starts Tomorrow!

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Join us tomorrow for our 10th Anniversary AIRR-C online event!

📢 This virtual two-day meeting marks the 10th anniversary of the founding of the AIRR Community. Join us for a celebration of the AIRR Community and two scientific sessions on “Specificity.”

⚠️ Service announcement: Each registration day is independent, with its own unique Zoom link! If you’d like to attend both days, make sure to register for each day separately to receive both Zoom links. Just joining for one day? No problem – simply register for your chosen day to get the correct link!

Register here: May 21 Link and May 22 Link

Final agenda:

 

New episode of the On AIRR podcast is here!

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In this episode of On AIRR, we welcome Dr. Bjoern Peters, Professor at the La Jolla Institute for Immunology, to discuss the crucial role of high-quality data in AI-driven immunological predictions and diagnostics.

Dr. Peters shares his journey from theoretical physics to MHC-binding prediction, leading to his work on the Immune Epitope Database (IEDB) — the world’s largest resource for immune epitope data. He highlights how good data often outcompete algorithmic improvements and discusses the challenges of data standardization in immunology. The conversation also delves into epitope prediction, AIRR sequencing for diagnostics, and the need for rigorous model validation in clinical applications.

Listen now via your favorite podcast platform or here: http://onairr.airr-community.org. New episodes will be released monthly.