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You are here: Home / AIRR Community / Join us for “Fundamentals of the Immune System”, Parts I & II

Join us for “Fundamentals of the Immune System”, Parts I & II

May 24, 2021 by Janice Reichert

Part I:  Organization of the immune system.
Thursday June 3, 2021, 11am – 1pm ET. 

Part II:  The immune system in action.
Tuesday June 15, 2021, 11am – 1pm ET.

In this 2-part workshop on the fundamentals of the immune system, Dr. Jamie Scott, Professor Emerita, Simon Fraser University, Canada, will first provide an overview of humoral and cellular immunity, and the basic structure of the immune system, including its cells, tissues and compartments, along with the “superhighway” of the immune system: the circulatory and lymphatic systems. In that context, innate and adaptive immune systems and their interaction, and the general timing and dynamics of immune responses will be presented.

The processes of lymphocyte development, including the various B- and T-cell subsets, positive and negative selection, and the genetic basis of B-cell and T-cell receptor diversification, will be presented to provide a clear idea of what adaptive-immune receptor repertoires (AIRRs) are, and in general terms, how they are currently assessed via high-throughput sequencing. Dr. Scott will then cover the signaling, activation, proliferation and differentiation of T-cell and B-cell clones in the context of lymphoid compartments where antigen is concentrated and presented to naïve and memory B and T cells. The role of co-stimulation in determining the type immune response generated will be emphasized.

In Part II, Dr. Scott will review the orchestration of systemic and mucosal immune responses, including the roles of tolerance and inflammation in these processes. Examples of immune responses to vaccines, chronic viral infection, and/or cancer, as well as autoimmunity, will be presented as variations on a common theme, reiterating the dynamics of the immune response. Some engineered immunotherapies, such as therapeutic antibodies, CAR-T cells and dendritic-cell vaccines, will be introduced as well.

The importance of AIRR-sequencing data to our understanding of immune responses will be emphasized throughout the latter half of this workshop.

Click here to register for Part I

Click here to register for Part II

Filed Under: AIRR Community, Immunology Tagged With: Adaptive Immune Receptor Repertoire Community, immunology

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AIRR Community News

Zooming into the Community III Starts Tomorrow!

May 20, 2025 By Lorissa Corrie

Join us tomorrow for our 10th Anniversary AIRR-C online event! 📢 This virtual two-day meeting marks the 10th anniversary of the founding of the AIRR Community. Join us for a celebration of the AIRR Community and two scientific sessions on “Specificity.” ⚠️ Service announcement: Each registration day is independent, with its own unique Zoom link! […]

New episode of the On AIRR podcast is here!

March 25, 2025 By Lorissa Corrie

In this episode of On AIRR, we welcome Dr. Bjoern Peters, Professor at the La Jolla Institute for Immunology, to discuss the crucial role of high-quality data in AI-driven immunological predictions and diagnostics. Dr. Peters shares his journey from theoretical physics to MHC-binding prediction, leading to his work on the Immune Epitope Database (IEDB) — […]

AIRR Community WG Calls

All times are in ET (Americas/New York)

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Webinar - Zooming into the AIRR Community III
11:00
Wed, May 21, 2025
Webinar - Zooming into the AIRR Community III
11:00
Thu, May 22, 2025
Call - ComRepo WG
11:00
Thu, June 5, 2025
Call - Standards WG
12:00
Thu, June 12, 2025
Call - Standards WG
14:00
Mon, June 16, 2025

Recent AIRR Publications

Lees W.D. et al. AIRR Community curation and standardised representation for immunoglobulin and T cell receptor germline sets (Immunoinformatics, 2023)

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