In this episode, we explore ReVAMPP (Research and Development of Vaccines and Monoclonal Antibodies for Pandemic Preparedness), an NIH-funded initiative focused on pathogens that pose significant public health risks, including emerging viruses with pandemic potential.

Together with Dr. Lauren Williamson and Dr. Robert Carnahan (Vanderbilt University Medical Center) and Dr. Matthew Vogt (University of North Carolina), we discuss how ReVAMPP enhances the development of effective vaccines and monoclonal antibodies. We dive into prototype pathogen strategies for identifying broadly neutralizing antibodies, the challenge of balancing breadth and potency in therapeutics, and innovative screening methods that could transform our ability to respond to future outbreaks.

Tune in for a behind-the-scenes look at how collaborative science is shaping the future of global health!

Listen now via your favorite podcast platform or here: http://onairr.airr-community.org. New episodes will be released monthly.

In this episode of On AIRR, we welcome Dr. Paul Thomas, of St. Jude Children’s Research Hospital.

Dr. Thomas shares his journey from immunoparasitology to pioneering TCR repertoire sequencing. The discussion covers the evolution from single-chain TCR sequencing to the development of high-throughput paired sequencing methods, culminating in the TIRTL-seq approach. Dr. Thomas explains the technical and computational challenges in TCR pairing, the innovations that made large-scale studies possible, and the importance of data quality and curation in the field. The episode highlights the impact of these advances on understanding immune responses and the future of AIRR-based diagnostics.

Listen now via your favorite podcast platform or here: http://onairr.airr-community.org. New episodes will be released monthly.