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On AIRR Podcast Episode 15 Now Available!

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In the latest episode of the On AIRR – An AIRR-C Podcast Series, Dr. Ulrik Stervbo and Dr. Zhaoqing Ding speak with Dr. Corey Watson and Dr. William Lees about the recent work by the Germline Database Working Group of the AIRR-Community. We discuss the challenges in creating a database to hold all relevant and potentially relevant germline information, especially in the light of increased discovery rate through technological advances and improved analysis pipelines. We also reflect on the complexity in handling personalized germline reference sets.

You can subscribe and listen in your favorite podcasting app or check out all of the On AIRR episodes here at http://onairr.airr-community.org or on the AIRR YT Channel. If you share podcast-related content in social media, please remember to use the hashtag #onairr!

Join us for the next AIRR-C webinar on Nov 7th!

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Drs. Encarnita Mariotti-Ferrandiz and Nina Luning Prak, members of the Adaptive Immune Receptor Repertoire (AIRR) Community Biological Resources Working Group, will describe quality control (QC) procedures for immune repertoire profiling. Dr. Mariotti-Ferrandiz will describe QC pipelines for sequencing of T cell receptor gene rearrangements that are in use in her laboratory in the Department of Immunology, Immunopathology and Immunotherapy at the Sorbonne. Next, Dr. Luning Prak will describe QC pipelines for sequencing of B cell receptor gene rearrangements that are in use in her laboratory and in the Human Immunology Core facility at the University of Pennsylvania. They will then focus on frequently asked questions and respond to other questions posed by attendees during a Q&A period.

Registration is open. Visit the AIRR Community Webinar Series website to learn more about this series, and access the recordings of past sessions.

Reconnect with the AIRR Data Commons: Your Gateway to Immunology Discoveries

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The AIRR Community continues to spearhead innovation in immunology research with the ever-expanding AIRR Data Commons (ADC). For those unfamiliar, the ADC is a pioneering initiative that enables the sharing of standardized Adaptive Immune Receptor Repertoire (AIRR) data. This resource hosts a wealth of information about the diverse array of antibody/B-cell and T-cell receptors that govern immune responses, obtained from bulk and single-cell sequencing technologies. By facilitating the exchange of this valuable data, the ADC enables researchers to gain deeper insights into immunity, disease progression, and therapeutic interventions.

From its inception in 2018 with under 400 million sequence annotations, the ADC has expanded into nine distributed repositories housing 89 studies, over 9800 sample repertoires, and an astonishing 5.2 billion sequence annotations. But this growth is not just about numbers – it’s about fostering collaboration and igniting discoveries. Scientists around the world can access a unified platform to discover, compare, and analyze immunological data, transcending the limitations of individual labs. This interconnectedness not only drives innovation but also eliminates redundancy, saving precious time and resources.

As we look to the future, the ADC is poised to play an even more pivotal role. Its flexible, collaborative framework and continued growth in data will likely attract interdisciplinary partnerships that foster a holistic understanding of the immune system’s complexities. Moreover, the integration of technologies such as machine learning and AI promise to extract deeper insights from the wealth of data, unraveling intricate mechanisms of the immune response.

The AIRR Community’s effort to build and maintain the ADC transcends geographical boundaries and institutional affiliations, exemplifying the spirit of scientific inquiry. As we celebrate the achievements thus far, we eagerly anticipate the advancements that this collaborative endeavor will bring to immunology research in the years to come.

The ADC can be searched interactively using a web user interface at the iReceptor Gateway or VDJServer Community Data Portal. To contribute to the ADC, consider setting up a local repository via the iReceptor Turnkey or submitting data through the VDJServer Community Data Portal.

September Seminar Series

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The September AIRR-C seminar is fast approaching! On September 28th at 7:00 PST/10:00 EST/16:00 CET, Pieter Meysman of the University of Antwerp will be discussing the applications of TCR-epitope prediction models and Felix Drost of Helmholtz Munich will be discussing the prediction of T cell receptor functionality against mutant epitopes.

Register now! The seminar will last approximately 90 minutes.

Register for the AIRR Community Special Event 2023 – Zooming in to the Community II

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Delve into the latest developments and clinical applications of adaptive immune receptor repertoire (AIRR) sequencing in this mid-cycle virtual event, on September 20 and 21, 2023.

What to Expect:

Community Updates: The event will kick off on September 20th with updates and discussions from AIRR Community Working Groups and Sub-committees. You’ll hear about the latest achievements and challenges from members of Biological Resources, Common Repository, Diagnostics, Germline Database, Legal and Ethics, Software, Standards, and more.

Strategic Planning: Dive deeper into the strategic planning session, where the AIRR-C’s Strategic Planning Sub-committee will present selected challenges and invite attendees to brainstorm strategies to address them. This session will focus on achieving recognition of the AIRR-C by the scientific community and adoption of AIRR-C standards, tools, and protocols.

Clinical Applications: On September 21st, the event will pivot to a special Diagnostics Session entitled “Bringing AIRR-seq to the clinic – mapping the challenges.” Explore the regulatory landscape for AIRR-seq-based products in clinical settings, including disease monitoring and diagnostics. 

Panel Discussion: Engage with the speakers during a panel discussion moderated by Dr. Enkelejda Miho, highlighting different aspects of regulatory pathways, with a focus on software as a medical device.

Why Attend:

This event provides a unique opportunity to connect with leading experts, researchers, and professionals in the field of immunology. Whether you’re involved in research, diagnostics, or data management, this AIRR Community Special Event 2023 offers a platform to explore the latest advancements, discuss challenges, and help shape the future of AIRR sequencing.

Event Details:

  • Date: September 20 & 21, 2023
  • Time: 7:00 – 10:00 PDT / 16:00 – 19:00 CEST
  • Location: Online
  • The event is free, but you must register to attend.

For more information, visit the event website.