In this episode of On AIRR, we welcome Dr. Paul Thomas, of St. Jude Children’s Research Hospital.
Dr. Thomas shares his journey from immunoparasitology to pioneering TCR repertoire sequencing. The discussion covers the evolution from single-chain TCR sequencing to the development of high-throughput paired sequencing methods, culminating in the TIRTL-seq approach. Dr. Thomas explains the technical and computational challenges in TCR pairing, the innovations that made large-scale studies possible, and the importance of data quality and curation in the field. The episode highlights the impact of these advances on understanding immune responses and the future of AIRR-based diagnostics.
Listen now via your favorite podcast platform or here: http://onairr.airr-community.org. New episodes will be released monthly.
