The Inferred Allele Review Sub-committee (IARC) was formed after the third AIRR-Community meeting in Rockville, MD in December 2017. The IARC is responsible for judging the validity of germline immunoglobulin and TCR genes inferred from AIRR-Seq and genomic data and submitting their findings to the IUIS T-cell Receptor and Immunoglobulin Nomenclature Review Committee. The work of the committee initially focused on human IGHV germline genes, but it is hoped that work will commence on the evaluation of other germline genes and species. Overall, the IARC aims to generate resources for and advocate for better practice in and understanding of IG and TR annotation and analysis in the community interested in studies of AIRR.
Achievements
- Process to enable move for integration of genomic and transcriptomic data
- Establish principle for review of genomic data
- Working with researchers and other AIRR-C groups to
- Establish macaque reference set
- Establish TCR reference set
- Integrate genomic data in the IARC process
- Establish lambda light chain reference set
- Establish TCR reference set
- Work with teams exploiting new technologies
- Review submitted to Immunoinformatics
- Expansion of competence in AIRR data of additional species
Further details, including evidence in support of the inferences, can be found at the OGRDB website.
Goals for 2024-26
- Evolve from sub-committee to review committee
- Incorporate genomic data in processes; process for larger submissions
- Consolidate interaction with TR-IG/IUIS nomenclature subcommittee
- Consolidation of the human TCR IARC process
Members
Co-leader: Mats Ohlin and Ayelet Peres
Members: 11 members
Products
Over all: Database for alleles of germline genes (continuous) and reference sets (through collaboration)
- 9 inferred immunoglobulin alleles submitted to and approved by IUIS
- A published commentary on the use of short read sequencing for AIRR allele discovery
- A submitted manuscript on Balb/c germline alleles identified by inference (co-authored with other WGs)
- Germline gene sets for Balb/c and C57BL/6 mouse strains published on OGRDB
Related Resources
- The OGRDB database documents the evaluation process of each submitted gene sequence, and provides access to evidence in support of affirmed inferences.
- The VDJbase database of genotypes and haplotypes is being developed in association with OGRDB, and provides evidence of the expression of germline genes in hundreds of individuals.
- Discussion of some issues arising from activities of the Germline Database Working Group can be found at the B-T.CR Wiki.
