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You are here: Home / AIRR Community / Reconnect with the AIRR Data Commons: Your Gateway to Immunology Discoveries

Reconnect with the AIRR Data Commons: Your Gateway to Immunology Discoveries

September 19, 2023 by Edel Aron

The AIRR Community continues to spearhead innovation in immunology research with the ever-expanding AIRR Data Commons (ADC). For those unfamiliar, the ADC is a pioneering initiative that enables the sharing of standardized Adaptive Immune Receptor Repertoire (AIRR) data. This resource hosts a wealth of information about the diverse array of antibody/B-cell and T-cell receptors that govern immune responses, obtained from bulk and single-cell sequencing technologies. By facilitating the exchange of this valuable data, the ADC enables researchers to gain deeper insights into immunity, disease progression, and therapeutic interventions.

From its inception in 2018 with under 400 million sequence annotations, the ADC has expanded into nine distributed repositories housing 89 studies, over 9800 sample repertoires, and an astonishing 5.2 billion sequence annotations. But this growth is not just about numbers – it’s about fostering collaboration and igniting discoveries. Scientists around the world can access a unified platform to discover, compare, and analyze immunological data, transcending the limitations of individual labs. This interconnectedness not only drives innovation but also eliminates redundancy, saving precious time and resources.

As we look to the future, the ADC is poised to play an even more pivotal role. Its flexible, collaborative framework and continued growth in data will likely attract interdisciplinary partnerships that foster a holistic understanding of the immune system’s complexities. Moreover, the integration of technologies such as machine learning and AI promise to extract deeper insights from the wealth of data, unraveling intricate mechanisms of the immune response.

The AIRR Community’s effort to build and maintain the ADC transcends geographical boundaries and institutional affiliations, exemplifying the spirit of scientific inquiry. As we celebrate the achievements thus far, we eagerly anticipate the advancements that this collaborative endeavor will bring to immunology research in the years to come.

The ADC can be searched interactively using a web user interface at the iReceptor Gateway or VDJServer Community Data Portal. To contribute to the ADC, consider setting up a local repository via the iReceptor Turnkey or submitting data through the VDJServer Community Data Portal.

Filed Under: ADC, AIRR Community Tagged With: Adaptive Immune Receptor Repertoire Community

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AIRR Community News

Zooming into the Community III Starts Tomorrow!

May 20, 2025 By Lorissa Corrie

Join us tomorrow for our 10th Anniversary AIRR-C online event! 📢 This virtual two-day meeting marks the 10th anniversary of the founding of the AIRR Community. Join us for a celebration of the AIRR Community and two scientific sessions on “Specificity.” ⚠️ Service announcement: Each registration day is independent, with its own unique Zoom link! […]

New episode of the On AIRR podcast is here!

March 25, 2025 By Lorissa Corrie

In this episode of On AIRR, we welcome Dr. Bjoern Peters, Professor at the La Jolla Institute for Immunology, to discuss the crucial role of high-quality data in AI-driven immunological predictions and diagnostics. Dr. Peters shares his journey from theoretical physics to MHC-binding prediction, leading to his work on the Immune Epitope Database (IEDB) — […]

AIRR Community WG Calls

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Webinar - Zooming into the AIRR Community III
11:00
Wed, May 21, 2025
Webinar - Zooming into the AIRR Community III
11:00
Thu, May 22, 2025
Call - ComRepo WG
11:00
Thu, June 5, 2025
Call - Standards WG
12:00
Thu, June 12, 2025
Call - Standards WG
14:00
Mon, June 16, 2025

Recent AIRR Publications

Lees W.D. et al. AIRR Community curation and standardised representation for immunoglobulin and T cell receptor germline sets (Immunoinformatics, 2023)

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