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You are here: Home / AIRR Community / COVID-19 AIRR-seq Vaccine Data Available!

COVID-19 AIRR-seq Vaccine Data Available!

May 31, 2021 by Pam Borghardt

The first AIRR-seq dataset from people who have been vaccinated against COVID-19 is now available in the AIRR Data Commons, accessible through the iReceptor Gateway. As more vaccination studies are made available, researchers will be able to compare these antibody/B-cell and T-cell receptor (BCR/TCR) sequences to the over 1 billion such sequences from studies of COVID-19 patients. Vaccines are designed to elicit the same immune response as that caused by natural infection, and the availability of data from vaccinated individuals will enable direct comparisons between these two types of responses. Such comparisons can determine the effect of different vaccine technologies, measure level of protection against circulating variants, and identify immune pressures leading to future variants. For example, this first vaccination study (Goel et al.) that is now curated in the AIRR Data Commons presents data from five recovered donors at three time points: before vaccination and after the first and second vaccinations, and the comparison suggests that COVID-19 recovered individuals may only require a single vaccine dose to achieve peak immune response. Similar comparisons as new vaccination studies become available will help inform public health decisions such as vaccine dosing and booster schedules.

The AIRR Community encourages and supports researchers in sharing their COVID-19 AIRR-seq data from natural infection and vaccination through the AIRR Data Commons. Now more than ever, access to curated, ready-to-analyze antibody and BCR/TCR sequence data will contribute to rapid health insights and public health strategies worldwide as we work to move through and beyond the COVID-19 global pandemic.

For an overview of the AIRR Data Commons, including demos on how to find and share data, see our recent webinar, The AIRR Data Commons: 4 billion reasons to store, analyze and share antibody/B-cell and T-cell receptor repertoire data.

Filed Under: AIRR Community, COVID-19, Vaccine Tagged With: Adaptive Immune Receptor Repertoire Community

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AIRR Community News

Zooming into the Community III Starts Tomorrow!

May 20, 2025 By Lorissa Corrie

Join us tomorrow for our 10th Anniversary AIRR-C online event! 📢 This virtual two-day meeting marks the 10th anniversary of the founding of the AIRR Community. Join us for a celebration of the AIRR Community and two scientific sessions on “Specificity.” ⚠️ Service announcement: Each registration day is independent, with its own unique Zoom link! […]

New episode of the On AIRR podcast is here!

March 25, 2025 By Lorissa Corrie

In this episode of On AIRR, we welcome Dr. Bjoern Peters, Professor at the La Jolla Institute for Immunology, to discuss the crucial role of high-quality data in AI-driven immunological predictions and diagnostics. Dr. Peters shares his journey from theoretical physics to MHC-binding prediction, leading to his work on the Immune Epitope Database (IEDB) — […]

AIRR Community WG Calls

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Webinar - Zooming into the AIRR Community III
11:00
Thu, May 22, 2025
Call - ComRepo WG
11:00
Thu, June 5, 2025
Call - Standards WG
12:00
Thu, June 12, 2025
Call - Standards WG
14:00
Mon, June 16, 2025
AIRR-C Executive Council Meeting
11:00
Thu, June 19, 2025

Recent AIRR Publications

Lees W.D. et al. AIRR Community curation and standardised representation for immunoglobulin and T cell receptor germline sets (Immunoinformatics, 2023)

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