This Working Group (WG) was formed to promote the development of complete and accurate sets of reference germline IG and TCR genes, and to promote the accurate analysis and reporting of the germline genes that can be identified in repertoire studies. The WG works to establish processes for documenting novel germline genes and alleles and standards for versioned, inclusive databases. The WG also provides guidance on specific topics relating to data assessment that may be referred to it by the Inferred Allele Review Sub-committee (IARC).
Goals for 2024-2026
- Publish a Human TR reference set (in conjunction with IARC)
- Continue work/updates on Human IG reference set
- Publish a Macaque IG reference set (in collaboration with the wider research community)
- Revive the mouse subgroup
- Set up subgroups for other species provided there is self-sustaining membership to support them
- Initiate the Outreach subgroup, provided we can find a volunteer to lead it
Resources
- OGRBD: the curated Open Germline Receptor Database
- VDJbase: a database of adaptive immune receptor germline genotypes and haplotypes
- Germline Database Working Group Project on the B-T.CR Wiki
- AIRR-C Germline Database Resources for the Immunoglobulin and T cell receptor genes
Members
Co-leaders: Jamie Heather and William Lees
Members:
Andrew Buchanan, Andrew Collins, Amit Upadhyay, Ayelet Peres, Chaim Schramm, Christian Busse, Corey Watson, Dylan Duchen, Eric Engelbrecht, Eve Richardson, Felix Breden, Ivana Mikocziova, Jamie Heather, Jamie Scott, Jesus Martinez, Katherine Jackson, Mansun Law, Mats Ohlin, Oscar Rodriguez, Pei-Lung Chen, Pierre Boudinot, Simone Olubo, Steve Bosinger, Susana Magadan, Swati Saha, William Gibson, William Lees
