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You are here: Home / The AIRR Community

The AIRR Community

The Adaptive Immune Receptor Repertoire (AIRR) Community of The Antibody Society is a research-driven group that is organizing and coordinating stakeholders in the use of next-generation sequencing technologies to study antibody/B-cell and T-cell receptor repertoires. Recent advances in sequencing technology have made it possible to sample the immune repertoire in exquisite detail. AIRR sequencing (AIRR-seq) has enormous promise for understanding the dynamics of the immune repertoire in vaccinology, infectious diseases, autoimmunity, and cancer biology, but also poses substantial challenges. The AIRR Community was established to meet these challenges.

The AIRR Community and its associated meetings and workshops are designed to develop and promote AIRR Data Standards and recommendations for:

  • obtaining, analyzing, curating and comparing/sharing AIRR-seq datasets;
  • reviewing AIRR-seq data analysis tools for AIRR compliance;
  • relating AIRR-seq datasets to other “big data” sets, such as microarray, flow cytometry, and single-cell gene-expression data; and
  • legal and ethical issues involving the use and sharing of AIRR-seq data sets derived from human sources.

The proceedings of the workshops, including the recommendations and action plans, are published to benefit the larger scientific community. The AIRR-C Comms is active on social media. To stay connected and learn the latest news in the AIRR Community, follow us on X, LinkedIn, Mastodon, or BlueSky, subscribe to our YouTube Channel, or check out the AIRR News page. You can also explore the B-T.CR forum and wiki and join the AIRR-C Slack.

What is the AIRR Community?

The idea of forming an Open Science grassroots community working with AIRR-seq data was the brainchild of Jamie Scott, Tom Kepler, and Felix Breden. From its conception in 2014, the AIRR Community grew and flourished, then joined The Antibody Society in 2018 as an official Committee. The AIRR Community now comprises a multidisciplinary group of several hundred stakeholders who are dedicated to the development of methods and standards for the generation, analysis and sharing of AIRR-seq data. Seven Working Groups and four Sub-Committees publish research articles describing standards for the generation, annotation, storage and sharing of AIRR-seq data following FAIR principles.

One result of these standards is the establishment of the AIRR Data Commons which provides public access to more than 80 MiARR compliant studies, including many COVID-19 studies, and their AIRR-seq data for query and download.  The Community also organizes meetings and workshops to report progress in the field and promote its standards as well as webinars and seminars to promote AIRR-seq related research. The governance structure of the AIRR Community (V22 adopted 2023.11.20) can be found in the Community Resources “members only” section of this website.

AIRR Community Meetings

The AIRR Community is excited to have recently hosted our seventh Meeting AIRR Community Meeting VII – Learnings and Perspectives which was held in Porto, Portugal on June 3-6, 2024.

For complete details about all AIRR Community Meetings, visit the AIRR-C Meetings page.

Benefits of Membership

Active members of the AIRR Community are involved in one or more of its Working Groups and Sub-Committees. These international groups meet regularly and are working on topics ranging from the validation and designation of germline V genes, software and data standards, addressing legal and ethical issues arising from the production, use and sharing of AIRR-seq data, manuscript development, to meeting planning. Natural networks of collaboration arise organically from these highly interactive projects. Thus, as a member of the AIRR Community, you will join a network of experts in the field who are actively solving real-world problems for the good of the scientific community.

If you are interested in learning more about the AIRR Community, please contact “info@airr-community.org” or visit the membership page and support AIRR research by becoming a member of this dynamic community.

AIRR Community News

Zooming into the Community III Starts Tomorrow!

May 20, 2025 By Lorissa Corrie

Join us tomorrow for our 10th Anniversary AIRR-C online event! 📢 This virtual two-day meeting marks the 10th anniversary of the founding of the AIRR Community. Join us for a celebration of the AIRR Community and two scientific sessions on “Specificity.” ⚠️ Service announcement: Each registration day is independent, with its own unique Zoom link! […]

New episode of the On AIRR podcast is here!

March 25, 2025 By Lorissa Corrie

In this episode of On AIRR, we welcome Dr. Bjoern Peters, Professor at the La Jolla Institute for Immunology, to discuss the crucial role of high-quality data in AI-driven immunological predictions and diagnostics. Dr. Peters shares his journey from theoretical physics to MHC-binding prediction, leading to his work on the Immune Epitope Database (IEDB) — […]

AIRR Community WG Calls

All times are in ET (Americas/New York)

Click here for full calendar view

Webinar - Zooming into the AIRR Community III
11:00
Thu, May 22, 2025
Call - ComRepo WG
11:00
Thu, June 5, 2025
Call - Standards WG
12:00
Thu, June 12, 2025
Call - Standards WG
14:00
Mon, June 16, 2025
AIRR-C Executive Council Meeting
11:00
Thu, June 19, 2025

Recent AIRR Publications

Lees W.D. et al. AIRR Community curation and standardised representation for immunoglobulin and T cell receptor germline sets (Immunoinformatics, 2023)

See all publications

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