Purpose:
The Inferred Allele Review Committee was formed after the third AIRR-Community meeting in Rockville, MD in December 2017. The IARC is responsible for judging the validity of germline immunoglobulin and TCR genes, inferred from RepSeq data. It will advise IMGT and the IUIS/IMGT nomenclature committee of their findings. It will also work with IMGT to make inferred sequences, and evidence in support of their existence, available to the AIRR community and other researchers. The work of the committee will initially focus on human IGHV germline genes, but in 2018 it is hoped that work will commence on the evaluation of other human germline genes, and on mouse and macaque genes. Over time, the IARC hopes to establish links with researchers who are defining the germline gene repertoires of other species, and to work with them to define procedures for the evaluation and documentation of inferred genes from all species.
Goals:
Plan for 2018:
- Develop a system for how this group will function in the short-/long-term. (e.g., will they operate formally as part of the IUIS/IMGT nomenclature committee?).
- Decide on the terms of service of members of the committee, and decide on procedures for the appointment of future members.
- Begin collating data for inferred human IGHV alleles from interested researchers, to establish the formal submission process, and to begin the evaluation of submitted sequences.
- Begin to develop criteria for the review and acceptance of inferred alleles for AIRR-relevant loci other than human IGHV.
Members:
Chair: Andrew Collins
Members: Martin Corcoran, Mats Ohlin, Cathrine Scheepers
Related Resources:
Visit the Germline Database Working Group Project on the B-T.CR Wiki.
Visit the The IgPdb Database, a curated repository of suspected allelic variants of human immunoglobulin germline genes.
Meeting Minutes:
IARC Meeting 8 19_3_18 minutes
IARC Meeting 9_ 28_3_18_ minutes
IARC Meeting 10_ 6_4_18_ minutes
IARC Meeting 11_ 13_4_18_ minutes
IARC Meeting 12_ 20_4_18_ minutes
IARC Meeting 13_ 2_5_18_ minutes
IARC Meeting 14_ 11_5_18_ minutes
IARC Meeting 15_ 18_5_18_ minutes
IARC Meeting 16_ 25_5_18_ minutes
IARC Meeting 17_ 1_6_18_ minutes
IARC Meeting 18_ 14_6_18_ minutes
IARC Meeting 19_ 19_6_18_ minutes
IARC Meeting 20_ 13_7_18_ minutes
IARC Meeting 21_ 27_7_18_ minutes
IARC Meeting 22_ 10_8_18_ minutes
IARC Meeting 23_ 24_8_18_ minutes
IARC Meeting 24_ 13_9_18_ minutes