The Adaptive Immune Receptor Repertoire (AIRR) Community is a research-driven group that is organizing and coordinating stakeholders in the use of next-generation sequencing (NGS) technologies to study antibody (Ab)/B-cell and T-cell receptor (TcR) repertoires. Recent advances in sequencing technology have made it possible to sample the immune repertoire in exquisite detail. AIRR sequencing has enormous promise for understanding the dynamics of the immune repertoire in vaccinology, infectious disease, autoimmunity, and cancer biology, but also poses substantial challenges. The AIRR Community was established to meet these challenges.
The AIRR Community and its associated meetings and workshops are designed to develop standards and recommendations for: 1) obtaining, analyzing, curating and comparing/sharing NGS AIRR datasets; 2) using and validating tools for analyzing AIRR data; 3) relating AIRR NGS datasets to other “big data” sets, such as microarray, flow cytometric, and MiSeq gene-expression data; and 4) legal and ethical issues involving the use and sharing of AIRR data sets derived from human sources. The proceedings of the workshops, including the recommendations and action plans, will be published to benefit the larger scientific community.
The Second AIRR Community Meeting was held June 27-30, 2016 at the National Institutes of Health (NIH)’s Fishers Lane facility. Please go to the Second AIRR Community Meeting page for the full meeting agenda, and a link to videos of the six sessions.
The Third AIRR Community Meeting was held December 3-6, 2017 at NIH’s Fishers Lane facility. Please go to the Third AIRR Community Meeting page for the full meeting agenda, and a link to the recorded videos of the sessions.
AIRR Community Publications:
In 2017 the AIRR Community Initiative published two papers:
- The first is an overview in Frontiers in Immunology, introducing the goals of the AIRR Community Initiative and inviting researchers to join our efforts.
- The second paper was published in Nature Immunology, and reports the Community’s recommendations for a minimal set of metadata that should be used to describe an AIRR-seq data set when published or when deposited in a AIRR-compliant repository.
Who is the AIRR Community?
The original AIRR Community meetings were the brainchild of Jamie Scott, Tom Kepler, and Felix Breden. The AIRR Community now comprises several hundred stakeholders, and includes working groups developing white papers, community standards, and planning future meetings.
- Felix Breden, Simon Fraser University
- Jamie Scott, Simon Fraser University
Organizing Committee for the AIRR Community Initiative:
- Lindsay Cowell, UT Southwestern Medical School (co-Lead, Common Repository Working Group)
- Corey Watson, University of Louisville Medical School (co-Lead, Common Repository Working Group)
- Danny Douek, NIH NIAID Vaccine Research Center
- Steven Kleinstein, Yale University (co-Lead, Minimal Standards Working Group)
- Nina Prak, University of Pennsylvania (co-Lead, Minimal Standards Working Group)
- Chaim Schramm, NIH (Lead, Tools and Resources)
- Tania Bubela, Faculty of Health Sciences, Simon Fraser University
Attendees at the 2017 AIRR Community Meeting III