We are seeking a talented and experienced scientist to join the Protein and Antibody Engineering group at Shire. The candidate will contribute to advancement of research and early development pipeline of innovative biotherapeutics for unmet medical needs. This individual is expected to have a strong foundation in molecular biology techniques and a collaborative approach to scientific inquiry. The ideal candidate should display a high level of attention to detail, demonstrate leadership potential and possess intellectual curiosity for learning new techniques and approaches to drug discovery. Primary responsibilities include generating antibody leads using phage display, protein engineering and high throughput screening.
• Develop and implement phage display and other antibody discovery strategies to advance novel biotherapeutic products through discovery and optimization stages.
• Responsible for cloning of various antibody formats (scFvs, Fabs, full length and bi-specific IgGs) into microbial and mammalian expression vector systems.
• Eukaryotic and mammalian protein expression and purification.
• Strong background in molecular cloning techniques including DNA and RNA extraction, PCR, RT-PCR, restriction enzyme digestions and site directed mutagenesis.
• Characterization of potential leads by ELISA and flow cytometry screening using manual and automated methods.
• Ability to accurately and clearly document, summarize and present experimental results.
• Utilize journal articles and other scientific resources to design and implement experimental methods.
Education & experience requirements:
MS with 5+ years of experience or PhD with 2-3 years of industry experience in Molecular Biology, Cell Biology, Biochemistry, Protein Chemistry or relevant field. Strong background in therapeutic antibody discovery and engineering.
Find more information about this job, located in Burlington, MA USA, and link to apply here.
Job posted: January 18, 2017
CTO/CSO/Director of R&D based in Paris
This position is at a company that has developed a unique platform utilizing droplet microfluidics for high throughput, single-cell, function-based screening of entire antibody-secreting B-cell populations.
The role holder will be a key part of the business’ senior management and will play a leading role in driving the business forwards by: 1) providing high level preclinical antibody drug discovery know-how that will enable the company to continue to engage on strategic projects with major pharmaceutical firms; and 2) providing input into defining the company’s own future drug development strategy, and then executing that program. The company has collaborative projects, mostly with pharmaceutical firms, so the role holder must be able to work at both strategic and operational levels to deliver customer projects. The role holder will be actively involved in attracting new partners, framing project plans that meet the needs of the potential partners, including budget and resources planning.
Applications should have more than 10 years of industrial experience within the field of antibody drug discovery, preferably at a larger pharmaceutical company, and must have a clear understanding of current requirements for good, industrial-standard antibody drug candidates and a comprehensive overview of antibody discovery technologies.
A work permit can be obtained for this role.
For more information, email Jayne.firstname.lastname@example.org
Job posted: January 3, 2017
Yale School of Medicine, Department of Pathology
1. Postdoctoral Associate Position (Computational Immunology)
2. Database/Bioinformatics Programmer (Computational Immunology)
- Yale School of Medicine, Department of Pathology, is seeking a highly motivated postdoctoral associate to work on the development and application of computational methods for the analysis of large-scale B cell immunoglobulin (Ig) repertoire sequencing data. Large-scale characterization of B cell receptor (BCR) and T cell receptor (TCR) repertoires is now feasible in humans. Driven by the dramatic improvements in high-throughput sequencing technologies, these repertoire sequencing (Rep-Seq) projects are opening up exciting avenues of inquiry. The successful candidate will join the Kleinstein lab at Yale, which has developed many widely used computational methods for Rep-Seq analysis. The ideal candidate will have strong quantitative and programming abilities, along with an interest in applying these skills to problems in biology. A Ph.D. in a quantitative discipline is desired (Bioinformatics, Computer Science, Statistics, Physics, Applied Mathematics, etc.). Interested candidates should forward a CV and short description of research interests together with the names and addresses of three references to Steven Kleinstein (email@example.com).
Find more information here.
Find more information here.
Job posted: December 21, 2016
President, Sales and Marketing
My client company is a leading antibody company with production facilities in Beijing and a headquarter office in San Diego focused on sales, marketing, distribution and management. The company was formed in 2001 based on a strategy of high throughput production and currently has a collection 9,000 commercially available polyclonal antibodies with 200 additional products added monthly. The product collection specializes in family oriented antibodies (Transcription Factor, Ion Channel, RNA Binding) providing a unique content not commercially available from their competitors.
The company is now seeking to expand their sales and marketing effort to increase our brand name and international visibility, to further penetrate the domestic and international markets and to enhance our distribution network. To accomplish these goals, they are seeking a hands on candidate for the position of President of Sales & Marketing reporting directly to the CEO to lead and coordinate our efforts. The ideal candidate shall have a minimum of 10 years of sales and marketing experience and spent at least 5 years at an executive level in the Biotechnology/Scientific industry. The person shall have a minimum of a bachelor’s degree in a field relevant to the position and possess exceptional written, verbal and interpersonal skills.
The selected candidate will have a track record that demonstrates the ability to increase revenues in the offering of antibody and bio-reagent products. They will have direct experience in developing, monitoring and managing e-marketing campaigns that result in successful outcomes as well as knowledge of alternative e-commerce strategies. The candidate will have experience in developing key U.S. accounts, managing international distributors, directing international advertising campaigns and managing major OEM partners. They will also have proven experience in successfully promoting both the organization’s and product brand names.
Interested candidates contact:
Career Interchange, Inc.
Job posted: November 19, 2016