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Antibody Classification
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Monoclonal Antibody Classification Using Differential Antigen Disruption (DAD)
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Abstract from the Antibody Society / IBC Antibody Engineering Conference, San Diego 2007
Monoclonal Antibody Classification Based on Epitope Binding Using Differential Antigen Disruption
A novel antigen-structure-based screening approach called differential antigen disruption (DAD) was developed (1). This method enables one to classify a large number of mAbs according to their epitopes in a robust and inexpensive manner. This mAb classification information can provide invaluable insights aiding mAb screening. The presentation will focus on the development and applications of the DAD technology for VelocImmune® human therapeutic antibody programs in Regeneron.
Ergang Shi, Ph.D.,
Senior Scientist, Regeneron Pharmaceuticals
1. Monoclonal antibody classification based on epitope-binding using differential antigen disruption. 2006. Ergang Shi a, Wen Fury a, Wentian Li, Warren Mikulka, Thomas Aldrich, Ashique Rafique, Gang Chen, Simon Hoffenberg, Thomas J. Daly, Czeslaw Radziejewski. Journal of Immunological Methods 314: 9–20.
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This page last modified 27 April, 2008 by Berend Tolner
The Antibody Society - PO Box 162 - Waban - Massachusetts - MA 02468 - USA
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